By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Proteins. According to news reporting from Philadelphia, Pennsylvania, by NewsRx journalists, research stated, "Low-density lipoprotein (LDL) plays a critical role in cholesterol transport and is closely linked to the progression of several diseases. This motivates the development of methods to study LDL behavior from the microscopic to whole-body level."
The news correspondents obtained a quote from the research from the University of Pennsylvania, "We have developed an approach to efficiently load LDL with a range of diagnostically active nanocrystals or hydrophobic agents. We performed focused experiments on LDL labeled with gold nanocrystals (Au-LDL). The labeling procedure had minimal effect on LDL size, morphology, or composition. Biological function was found to be maintained from both in vitro and in vivo experiments. Tumor-bearing mice were injected intravenously with LDL, DIR-LDL, Au-LDL, or a gold-loaded nanoemulsion. LDL accumulation in the tumors was detected with whole-body imaging methods, such as computed tomography (CT), spectral CT, and fluorescence imaging. Cellular localization was studied with transmission electron microscopy and fluorescence techniques."
According to the news reporters, the research concluded: "This LDL labeling procedure should permit the study of lipoprotein biointeractions in unprecedented detail."
For more information on this research see: Gold Nanocrystal Labeling Allows Low-Density Lipoprotein Imaging from the Subcellular to Macroscopic Level. ACS Nano, 2013;7(11):9761-9770. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
Our news journalists report that additional information may be obtained by contacting I.E. Allijn, University of Pennsylvania, Perelman Sch Med, Dept. of Radiol, Philadelphia, PA 19104, United States. Additional authors for this research include W. Leong, J. Tang, A. Gianella, A.J. Mieszawska, F. Fay, G. Ma, S. Russell, C.B. Callo, R.E. Gordon, E. Korkmaz, J.A. Post, Y.M. Zhao, H.C. Gerritsen, A. Thran, R. Proksa, H. Daerr, G. Storm, V. Fuster, E.A. Fisher and Fayad (see also Proteins).
Keywords for this news article include: Lipids, Nanocrystal, Philadelphia, Pennsylvania, Lipoproteins, United States, Nanotechnology, Emerging Technologies, North and Central America
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