By a News Reporter-Staff News Editor at Physics Week -- Current study results on Nanomaterials have been published. According to news reporting out of Beijing, People's Republic of China, by VerticalNews editors, research stated, "Regarding the importance of the biological effects of nanomaterials, there is still limited knowledge about the binding structure and stability of the protein corona on nanomaterials and the subsequent impacts. Here we designed a hard serum albumin protein corona (BSA) on CTAB-coated gold nanorods (AuNRs) and captured the structure of protein adsorption using synchrotron radiation X-ray absorption spectroscopy, microbeam X-ray fluorescent spectroscopy, and circular dichroism in combination with molecular dynamics simulations."
Our news journalists obtained a quote from the research from National Center for Nanoscience and Technology, "The protein adsorption is attributed to at least 12 Au-S bonds and the stable corona reduced the cytotoxicity of CTAB/AuNRs. These combined strategies using physical, chemical, and biological approaches will improve our understanding of the protective effects of protein coronas against the toxicity of nanomaterials."
According to the news editors, the research concluded: "These findings have shed light on a new strategy for studying interactions between proteins and nanomaterials, and this information will help further guide the rational design of nanomaterials for safe and effective biomedical applications."
For more information on this research see: Revealing the Binding Structure of the Protein Corona on Gold Nanorods Using Synchrotron Radiation-Based Techniques: Understanding the Reduced Damage in Cell Membranes. Journal of the American Chemical Society, 2013;135(46):17359-17368. Journal of the American Chemical Society can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of the American Chemical Society - www.pubs.acs.org/journal/jacsat)
Our news journalists report that additional information may be obtained by contacting L.M. Wang, Natl Center Nanosci & Technol China, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing, People's Republic of China. Additional authors for this research include J.Y. Li, J. Pan, X.M. Jiang, Y.L. Ji, Y.F. Li, Y. Qu, Y.L. Zhao, X.C. Wu and C.Y. Chen.
Keywords for this news article include: Asia, Beijing, Nanorod, Physics, Synchrotrons, Nanotechnology, Emerging Technologies, People's Republic of China
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