By a News Reporter-Staff News Editor at Cancer Weekly -- Research findings on Nanoparticles are discussed in a new report. According to news originating from Berlin, Germany, by NewsRx correspondents, research stated, "Micromixer technology was used to prepare polymeric vesicles (PluronicŪ L-121) dual loaded with the anti-cancer drug camptothecin and magnetic nanoparticles. Successful incorporation of the magnetic nanoparticles was confirmed by transmission electron microscopy."
Our news journalists obtained a quote from the research from Institute for Materials Research, "Dynamic light scattering measurements showed a relatively narrow size distribution of the hybrid polymersomes. Camptothecin polymersomes reduced the cell viability of prostate cancer cells (PC-3) measured after 72 h significantly, while drug-free polymersomes showed no cytotoxic effects. Covalent attachment of a cancer targeting peptide (bombesin) as well as a fluorescent label (Alexa FluorŪ 647) to the hybrid polymersomes was performed and specific cell binding and internalization were shown by flow cytometry and confocal microscopy. Relaxometry measurements clearly demonstrated the capacity of magnetic polymersomes to generate significant T2-weighted MRI contrast and potentially allow for direct monitoring of the biodistribution of the polymersomes."
According to the news editors, the research concluded: "Micromixer technology as an easy, fast and efficient way to manufacture hybrid polymersomes as theranostic drug delivery devices is a further step from basic research to personalized medicine."
For more information on this research see: Continuously manufactured magnetic polymersomes--a versatile tool (not only) for targeted cancer therapy. Nanoscale, 2013;5(23):11385-93. (Royal Society of Chemistry - www.rsc.org/; Nanoscale - pubs.rsc.org/en/journals/journalissues/nr)
The news correspondents report that additional information may be obtained from R. Bleul, BAM Federal Institute for Materials Research and Testing, 12205 Berlin, Germany. Additional authors for this research include R. Thiermann, G.U. Marten, M.J. House, T.G. St Pierre, U.O. Hafeli and M. Maskos (see also Nanoparticles).
Keywords for this news article include: Berlin, Europe, Cancer, Germany, Therapy, Oncology, Nanotechnology, Emerging Technologies.
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