Here he worked on an advanced technology, where it is possible to see how microRNA binds to the mRNA.
MicroRNA works by binding to so-called Ago proteins and guiding these proteins to specific locations on the mRNA. The mRNAs are the copies of the DNA's genes, which are translated directly into protein.
The Ago proteins bind to both the microRNA and the mRNA at the same time, which either means that the mRNAs are broken down, or that the so-called translation into protein is otherwise hindered.
This special Ago protein, together with the RNA that was bound to it, could be purified from the brain tissue of the mice with the help of an antibody. The researchers were thus able to determine where the different microRNA in the neurons bind.
MicroRNA-128 turned out to be the microRNA that controls the greatest number of mRNAs in the brains of the mice - more specifically in the neurons!
Experiments on mice
Together with his former supervisor
Experiments on mice show that you can check the amount of microRNA-128 in neurons that respond to dopamine, and thus also check how it affects a wide variety of gene expression in these neurons, which results in an altered activation of the neurons. "A large volume of microRNA-128 results in a lower neuron activity and can help to hamper the degree of activation in the musculoskeletal system.
Such a strong reaction to a change of the microRNA level is seen extremely rarely.
The reason for the intense effect of the microRNA 128 reduction in neurons must probably be found in the fact that microRNA 128 regulates a lot of the mRNAs (and, thus, many gene expressions) ", explains
Mice are the first step - humans are the next
The new research is not yet transferable to humans, but
In addition to microRNA 128, microRNA 134 also has an impact on epilepsy, particularly under the microscope.
Keywords for this news article include: Epilepsy, Genetics, Peptides, Proteins, Amino Acids, Brain Diseases,
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC
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