By a News Reporter-Staff News Editor at Drug Week -- A new study on Peptide Proteins is now available. According to news originating from Karachi, Pakistan, by NewsRx correspondents, research stated, "Angiotensin converting enzyme (ACE) is a key player of Renin Angiotensin System (RAS), involved in conversion of active product, angiotensin-II. Alterations in RAS have been implicated in the pathophysiology of various diseases involving heart, kidney, lung and liver."
Our news journalists obtained a quote from the research from the University of Karachi, "This study is designed to investigate the association of ACE gene expression in induction of liver cirrhosis in rats. Total 12 male albino Wistar rats were selected and divided in two groups. Control group received 0.9% NaCl, where as Test group received thioacidamide (TAA), dissolved in 0.9%NaCl, injected intraperitoneally at a dosage of 200mg/Kg of body weight, twice a week for 12 weeks. The rats were decapitated and blood sample was collected at the end of experimental period and used for liver functions, enzyme activity, antioxidant enzymes and lipid peroxidation estimations. Genomic DNA was isolated from excised tissue determine the ACE genotypes using specific primers. The ACE gene expression in liver tissue was assessed using the quantitative RT-PCR method. The activity of ALT, total and direct bilirubin, SOD and CAT levels were significantly high (p
According to the news editors, the research concluded: "The development of specific modulators of ACE activity and function, in future, will help determine the role of ACE and its genetic variants in the pathophysiology of liver disease."
For more information on this research see: Angiotensin converting enzyme (ACE) gene expression in experimentally induced liver cirrhosis in rats. Pakistan Journal of Pharmaceutical Sciences, 2013;26(5):853-7 (see also Peptide Proteins).
The news correspondents report that additional information may be obtained from S.M. Shahid, The Karachi Institute of Biotechnology & Genetic Engineering (KIBGE), University of Karachi, Karachi, Pakistan. Additional authors for this research include S.N. Fatima and T. Mahboob.
Keywords for this news article include: Asia, Karachi, Pakistan, Autacoids, Angiotensins, Neuropeptides, Oligopeptides, Peptide Hormones, Peptide Proteins, Enzymes and Coenzymes.
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