By a News Reporter-Staff News Editor at Drug Week -- Research findings on Drugs and Therapies are discussed in a new report. According to news reporting out of Adelaide, Australia, by NewsRx editors, research stated, "The purpose of this study was to investigate the colloidal structures formed on digestion of medium chain triglyceride (MCT) with a specific objective of identifying and characterizing a previously reported vesicular phase, which has been linked to supersaturation and anomalous digestion kinetics, and to evaluate the influence of lipid mass and enzyme inhibition on self assembled structure. MCT was digested in vitro and nanostructure was monitored in real time using synchrotron small angle X-ray scattering (sSAXS), and morphology was studied using cryogenic transmission electron microscopy (cryo-TEM)."
Our news journalists obtained a quote from the research from the University of South Australia, "Formation of the putative vesicular phase formed on digestion of MCT was confirmed and its structural attributes were determined. Vesicle formation was dependent on lipid mass and bile salt concentration. The use of enzyme inhibitor for offline analysis of lipolysis samples did influence structural aspects of the digestion medium when compared to real time evaluation. The formation of a vesicular phase was directly linked to the kinetics of lipid digestion. Vesicle formation is linked to lipid mass, or more specifically the ratio of lipid to bile salts present in the digestion mixture."
According to the news editors, the research concluded: "Inhibition of lipase to halt digestion during sampling for offline analysis must be done with caution as structural aspects were shown to differ for the MCT digests with and without inhibitor present."
For more information on this research see: Structural Aspects of Digestion of Medium Chain Triglycerides Studied in Real Time Using sSAXS and Cryo-TEM. Pharmaceutical Research, 2013;30(12):3088-3100. Pharmaceutical Research can be contacted at: Springer, Plenum Publishers, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Pharmaceutical Research - www.springerlink.com/content/0724-8741/)
Our news journalists report that additional information may be obtained by contacting S. Phan, University of South Australia, Ian Wark Res Inst, Adelaide, SA, Australia. Additional authors for this research include A. Hawley, X. Mulet, L. Waddington, C.A. Prestidge and B.J. Boyd (see also Drugs and Therapies).
Keywords for this news article include: Adelaide, Drugs and Therapies, Australia and New Zealand
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