By a News Reporter-Staff News Editor at Journal of Technology -- Investigators discuss new findings in Biomaterials. According to news reporting originating from Troy, New York, by VerticalNews correspondents, research stated, "Mucus secretion from the body is ubiquitous, and finding materials that resist mucus adhesion is a major technological challenge. Here, using a high throughput platform with photo-induced graft polymerization, we first rapidly synthesized, screened and tested a library of 55 different surfaces from six functional monomer classes to discover porcine intestinal low mucus adhesion surfaces using a 1h static mucus adsorption protocol."
Our news editors obtained a quote from the research from Rensselaer Polytechnic Institute, "From this preliminary screen, two chemistries, a zwitterionic ([2-(acryloyloxy)ethyl] trimethylammonium chloride) and a multiple hydroxyl (N-[tris(hydroxymethyl)methyl]acrylamide) surface, exhibited significantly low mucus adhesion from a Langmuir-type isotherm when exposed to increasing concentrations of mucus for 24 h. Apolar or hydrophobic interactions were likely the dominant attractive forces during mucus binding since many polar or hydrophilic monomers reduced mucus adhesion. Hansen solubility parameters were used to illustrate the importance of monomer polarity and hydrogen bonding in reducing mucus adsorption."
According to the news editors, the research concluded: "For a series of polyethylene glycol (PEG) monomers with changing molecular weight from 144 g mol? to 1100 g mol?, we observed an excellent linear correlation (R=0.998) between relative amount adsorbed and the distance from a water point in a specialized Hansen solubility parameter plot, emphasizing the role of surface-water interactions for PEG modified surfaces."
For more information on this research see: Discovery of low mucus adhesion surfaces. Acta Biomaterialia, 2013;9(2):5201-7. (Elsevier - www.elsevier.com; Acta Biomaterialia - www.elsevier.com/wps/product/cws_home/702994)
The news editors report that additional information may be obtained by contacting M. Gu, Howard P Isermann Dept. of Chemical and Biological Engineering and The Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180-3590, United States. Additional authors for this research include H. Yildiz, R. Carrier and G. Belfort.
Keywords for this news article include: Troy, New York, Biomaterials, United States, North and Central America.
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