By a News Reporter-Staff News Editor at Vaccine Weekly -- New research on Immunization and Public Health is the subject of a report. According to news reporting out of Irvine, California, by NewsRx editors, research stated, "Many current cancer vaccine strategies suffer from the inability to mount a CD8 T cell response that is strong enough to overcome the low immunogenicity of tumors. Viruses naturally possess the sizes, geometries, and physical properties for which the immune system has evolved to recognize, and mimicking those properties with nanoparticles can produce robust platforms for vaccine design."
Our news journalists obtained a quote from the research from the University of California, "Using the nonviral E2 core of pyruvate dehydrogenase, we have engineered a viral-mimicking vaccine platform capable of encapsulating dendritic cell (DO-activating CpG molecules in an acid-releasable manner and displaying MHC I-restricted SIINFEKL peptide epitopes. Encapsulated CpG activated bone marrow-derived DCs at a 25-fold lower concentration in vitro when delivered with the E2 nanoparticle than with unbound CpG alone. Combining CpG and SIINFEKL within a single multifunctional particle induced similar to 3-fold greater SIINFEKL display on MHC I by DCs over unbound peptide. Importantly, combining CpG and SIINFEKL to the E2 nanoparticle for simultaneous temporal and spatial delivery to DCs showed increased and prolonged CD8 T cell activation, relative to free peptide or peptide-bound E2."
According to the news editors, the research concluded: "By codelivering peptide epitopes and CpG activator in a particle of optimal DC-uptake size, we demonstrate the ability of a noninfectious protein nanoparticle to mimic viral properties and facilitate enhanced DC activation and cross-presentation."
For more information on this research see: Biomimetic Protein Nanoparticles Facilitate Enhanced Dendritic Cell Activation and Cross-Presentation. ACS Nano, 2013;7(11):9743-9752. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
Our news journalists report that additional information may be obtained by contacting N.M. Molino, University of California, Inst Immunol, Irvine, CA 92697, United States. Additional authors for this research include A.K.L. Anderson, E.L. Nelson and S.W. Wang (see also Immunization and Public Health).
Keywords for this news article include: Antigen-Presenting Cells, Irvine, California, Immunology, Biomimetics, United States, Bioengineering, Dendritic Cells, Bionanotechnology, Nanobiotechnology, Emerging Technologies, Protein Nanoparticles, North and Central America, Mononuclear Phagocyte System, Immunization and Public Health
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