The news reporters obtained a quote from the research from
According to the news reporters, the research concluded: "The findings are consistent with a charge titration effect in which, in the absence of NaCl, (1) hybridization does not occur at room temperature if an average of 17.5 or less Mg2+ ions are bound per T-40 strand, which is not reached until the bulk Mg2+ concentration approaches 0.5 mM; (2) hybridization proceeds, albeit with low duplex stability having an average T-m of 31(3)degrees C, if an average of 17.5-18.0 Mg2+ ions are bound; and (3) highly stable duplexes having a T-m of 64(2)degrees C form if 18.5-19.0 Mg2+ ions are bound, corresponding to saturation of the T-40 strand."
For more information on this research see: Counting the Number of Magnesium Ions Bound to the Surface-Immobilized Thymine Oligonucleotides That Comprise Spherical Nucleic Acids.
Our news correspondents report that additional information may be obtained by contacting S.R. Walter,
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