Imec, a world leading nanoelectronics research center, proudly announces that Prof. Dr.
The single cell analyzer that Prof. Dr. Lagae and her team will develop for the SCALPEL project is based on lens free digital imaging to analyze the physical morphology of single cells flowing at high speeds through a microfluidic network with gentle cell sorting switches to route the cells towards different outlets. It thus combines the virtues of microscopic high content imaging with the virtues of automated high throughput single cell analysis and sorting at a fraction of the cost. Because all optomechanical components, such as lenses, detectors, and nozzles, are replaced by nanoelectronics and advanced signal processing technology, the devices will be cheap and compact.
Currently, single cell analysis remains tedious with many different instruments and protocols, typically taking a few days of intense, hands-on work. The process not only slows down research, but also hinders the translation to application in clinical practice.
Billions of dollars have been spent trying to cure primary tumors, but very little was spent in trying to detect or kill circulating tumor cells causing metastasis. Metastasis is responsible for more than 90 percent of cancer-related deaths, and originates from single circulating tumor cells, spreading via the blood stream to seed new tumors. Detection of those highly aggressive circulating tumor cells at an early stage would greatly improve the chance of survival. This is an example of an application that could greatly benefit from the SCALPEL cell sorter. Prof. Lagae will collaborate with Prof.
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