By a News Reporter-Staff News Editor at Science Letter -- Investigators discuss new findings in Alkenes. According to news originating from Tianjin, People's Republic of China, by NewsRx correspondents, research stated, "The efficacy of magnetic nanoparticles (MNPs) for biomedical applications depends on the specic targeting capacity, blood circulation time and magnetic susceptibility. Functionalized chitosan-coated Fe3O4 nanoparticles (CS-coated Fe3O4 NPs) were synthesized by a non-solvent-aided coacervation procedure followed by a chemical crosslinking procedure."
Our news journalists obtained a quote from the research from Peking Union Medical College, "The surfaces of CS-coated Fe3O4 NPs were successfully functionalized with folate-poly(ethylene glycol)-COOH (FA-PEG) to obtain novel FA-PEG-CS-coated Fe3O4 NPs endowed with long blood circulation and specic targeting capacity. The as-synthesized NPs were characterized by dynamic light scattering, transmission electron microscope, X-ray diffraction, thermal gravimetric analysis, vibration sample magnetometer, Fourier transform infrared spectroscopy, and confocal laser scanning microscopy. As a result, the novel FA-PEG-CS-coated Fe3O4 NPs showed excellent biocompatibility, magnetic properties, good dispersibility, and proper hydrodynamic sizes in an aqueous medium. The specific targeting capacity of the as-synthesized NPs to cancer cells was also investigated. It was observed that the uptake of the FA-PEG-CS-coated Fe3O4 NPs by HeLa cells was significantly enhanced compared to the CS-coated Fe3O4 NPs and mPEG-CS-coated Fe3O4 NPs."
According to the news editors, the research concluded: "These results clearly indicate that our novel FA-PEG-CS-coated Fe3O4 NPs with remarkable specific targeting capacity, long blood circulation, and superparamagnetism hold great promise for biomedical applications, including targeted drug delivery and hyperthermia therapy."
For more information on this research see: Development of multifunctional folate-poly(ethylene glycol)-chitosan-coated Fe3O4 nanoparticles for biomedical applications. Macromolecular Research, 2014;22(1):58-66. Macromolecular Research can be contacted at: Polymer Soc Korea, Room 601, Hatchon Building, 831 Yeoksam-Dong, Kangnam-Ku, Seoul 135-792, South Korea. (Springer - www.springer.com; Macromolecular Research - www.springerlink.com/content/1598-5032/)
The news correspondents report that additional information may be obtained from S.F. Zhou, Peking Union Med College, Tianjin 300192, People's Republic of China. Additional authors for this research include Y. Li, F. Cui, M.M. Jia, X.R. Yang, Y.G. Wang, L.Y. Xie, Q.Q. Zhang and Z.Q. Hou (see also Alkenes).
Keywords for this news article include: Asia, Tianjin, Alkenes, Nanoparticle, Nanotechnology, Ethylene Glycols, Emerging Technologies, People's Republic of China
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