By a News Reporter-Staff News Editor at Science Letter -- Investigators publish new report on Enzymes and Coenzymes. According to news reporting originating from Washington, District of Columbia, by NewsRx correspondents, research stated, "Self-assembly of small molecules, as a more common phenomenon than one previously thought, can be either beneficial or detrimental to cells. Despite its profound biological implications, how the self-assembly of small molecules behave in a cellular environment is largely unknown and barely explored."
Our news editors obtained a quote from the research from Howard University, "This work studies four fluorescent molecules that consist of the same peptidic backbone (e.g., Phe-Phe-Lys) and enzyme trigger (e.g., a phosphotyrosine residue), but bear different fluorophores on the side chain of the lysine residue of the peptidic motif. These molecules, however, exhibit a different ability of self-assembly before and after enzymatic transformation (e.g., dephosphorylation). Fluorescent imaging reveals that self-assembly directly affects the distribution of these small molecules in a cellular environment. Moreover, cell viability tests suggest that the states and the locations of the molecular assemblies in the cellular environment control the phenotypes of the cells. For example, the molecular nanofibers of one of the small molecules apparently stabilize actin filaments and alleviate the insult of an F-actin toxin (e.g., latrunculin A). Combining fluorescent imaging and enzyme-instructed self-assembly of small peptidic molecules, this work demonstrates self-assembly as a key factor for dictating the spatial distribution of small molecules in a cellular environment."
According to the news editors, the research concluded: "In addition, it illustrates a useful approach, based on enzyme-instructed self-assembly of small molecules, to modulate spatiotemporal profiles of small molecules in a cellular environment, which allows the use of the emergent properties of small molecules to control the fate of cells."
For more information on this research see: Imaging Self-Assembly Dependent Spatial Distribution of Small Molecules in a Cellular Environment. Langmuir, 2013;29(49):15191-15200. Langmuir can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Langmuir - www.pubs.acs.org/journal/langd5)
The news editors report that additional information may be obtained by contacting Y. Gao, Howard University, Dept. of Chem Engn, Washington, DC 20059, United States. Additional authors for this research include Y. Kuang, X.W. Du, J. Zhou, P. Chandran, F. Horkay and B. Xu (see also Enzymes and Coenzymes).
Keywords for this news article include: Washington, United States, District of Columbia, Enzymes and Coenzymes, North and Central America
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