By a News Reporter-Staff News Editor at Science Letter -- A new study on Ovum is now available. According to news reporting from Aix en Provence, France, by NewsRx journalists, research stated, "Cerium dioxide nanoparticles (CeO2 ENPs) are on the priority list of nanomaterials requiring evaluation. We performed in vitro assays on mature mouse oocytes incubated with CeO2 ENPs to study (1) physicochemical biotransformation of ENPs in culture medium; (2) ultrastructural interactions with follicular cells and oocytes using Transmission Electron Microscopy (TEM); (3) genotoxicity of CeO2 ENPs on follicular cells and oocytes using a comet assay."
The news correspondents obtained a quote from the research, "DNA damage was quantified as Olive Tail Moment. We show that ENPs aggregated, but their crystal structure remained stable in culture medium. TEM showed endocytosis of CeO2 ENP aggregates in follicular cells. In oocytes, CeO2 ENP aggregates were only observed around the zona pellucida (ZP). The comet assay revealed significant DNA damage in follicular cells. In oocytes, the comet assay showed a dose-related increase in DNA damage and a significant increase only at the highest concentrations. DNA damage decreased significantly both in follicular cells and in oocytes when an anti-oxidant agent was added in the culture medium."
According to the news reporters, the research concluded: "We hypothesise that at low concentrations of CeO2 ENPs oocytes could be protected against indirect oxidative stress due to a double defence system composed of follicular cells and ZP."
For more information on this research see: Ultrastructural Interactions and Genotoxicity Assay of Cerium Dioxide Nanoparticles on Mouse Oocytes. International Journal of Molecular Sciences, 2013;14(11):21613-21628. International Journal of Molecular Sciences can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland (see also Ovum).
Our news journalists report that additional information may be obtained by contacting B. Courbiere, iCEINT, F-13545 Aix En Provence, France. Additional authors for this research include M. Auffan, R. Rollais, V. Tassistro, A. Bonnefoy, A. Botta, J. Rose, T. Orsiere and J. Perrin.
Keywords for this news article include: Ovum, France, Europe, Oocytes, DNA Damage, Proteomics, DNA Research, Nanoparticle, Nanotechnology, Aix en Provence, Deoxyribonucleic Acid, Emerging Technologies
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