Researchers at the
Elham Cheraghipour, a researcher of the project, said cationic albumin-conjugated magnetite nanoparticles (MNPs) of about 10?nm were synthesized through co-precipitation, and citric acid was used to stabilize the MNP suspension, ISNA reported.
She added that albumin was cutinized by replacing anionic side chain groups with cationic groups.
"The surface modification of the MNPs was provided by cationic albumin, which was covalently conjugated to carboxylic acid functions located at the distal end of the MNPs' surface by carbodiimide chemistry," she said.
Cheraghipour further said stable super-paramagnetic suspensions with particle sizes of 140?nm and saturation magnetization of 67?emu/g were obtained, which do not have the disadvantage of eventual desorption of physical attachment.
"We also analyzed the potential of these particles for magnetic fluid hyperthermia by determining the specific absorption rate with a constant frequency of 215 kHz; the temperature increase of the particles was 30.8?°C," she said.
Cheraghipour concluded that this study demonstrates the high efficiency of these nano-heaters.
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