By a News Reporter-Staff News Editor at Science Letter -- Fresh data on Nanoparticles are presented in a new report. According to news reporting out of Wuhan, People's Republic of China, by NewsRx editors, research stated, "Hydrophobically modified chitosan (hmC) is a self-assembling polymer that has attracted recent attention for many applications, including as a hemostatic agent. One limitation with chitosan and its derivatives like hmC is that these polymers are soluble in water only under acidic conditions (because the pK(a) of chitosan is about 6.5), which could be undesirable for biomedical applications."
Our news journalists obtained a quote from the research from the Wuhan University of Technology, "To circumvent this limitation, we have synthesized a derivative of a C-12-tailed hmC that is soluble in water at neutral pH. This water-soluble hmC (ws-hmC) is obtained by grafting O-carboxymethyl groups onto some of the primary hydroxyls on hmC. The solubility of ws-hmC at neutral pH is shown to be the result of a net anionic character for the polymer due to ionization of the carboxymethyl groups (in comparison, hmC is cationic). We also demonstrate that ws-hmC retains the self-assembling properties of hmC. Specifically, ws-hmC is able to induce gelation at neutral pH in dispersions of anionic surfactant vesicles as well as polymethylmethacrylate latex nanoparticles. Gelation is attributed to hydrophobic interactions between the hydrophobes on ws-hmC with vesicle bilayers and nanoparticle surfaces."
According to the news editors, the research concluded: "In each case, gelation can be reversed by the addition of alpha-cyclodextrin, a supramolecule with a hydrophobic cavity that sequesters the hydrophobes on the polymer."
For more information on this research see: Gelation of Vesicles and Nanoparticles Using Water-Soluble Hydrophobically Modified Chitosan. Langmuir, 2013;29(49):15302-15308. Langmuir can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Langmuir - www.pubs.acs.org/journal/langd5)
Our news journalists report that additional information may be obtained by contacting Y.J. Chen, Wuhan Univ Technol, Sch Mat Sci & Engn, Wuhan 430070, People's Republic of China. Additional authors for this research include V. Javvaji, I.C. MacIntire and S.R. Raghavan (see also Nanoparticles).
Keywords for this news article include: Asia, Wuhan, Nanotechnology, Emerging Technologies, People's Republic of China
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