By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Diarylheptanoids have been published. According to news originating from Fort Worth, Texas, by NewsRx correspondents, research stated, "Cardiac toxicity is the foremost reason for drug discontinuation from development to clinical evaluation and post market surveillance [Fung 35:293-317, 2001; Piccini 158:317-326 2009]. The Food and Drug Administration (FDA) has rejected many potential pharmaceutical agents due to QT prolongation effects."
Our news journalists obtained a quote from the research from the University of North Texas, "Since drug development and FDA approval takes an enormous amount of time, money and effort with high failure rates, there is an increased focus on rescuing drugs that cause QT prolongation. If these otherwise safe and potent drugs were formulated in a unique way so as to mitigate the QT prolongation associated with them, these potent drugs may get FDA approval for clinical use. Rescuing these compounds not only benefit the patients who need them but also require much less time and money thus leading to faster clinical translation. In this study, we chose curcumin as our drug of choice since it has been shown to posses anti-tumor properties against various cancers with limited toxicity. The major limitations with this pharmacologically active drug are (a) its ability to prolong QT by inhibiting the hERG channel and (b) its low bioavailability. In our previous studies, we found that lipids have protective actions against hERG channel inhibition and therefore QT prolongation. Results of the manual patch clamp assay of HEK 293 cells clearly illustrated that our hybrid nanocurcumin formulation prevented the curcumin induced inhibition of hERG K+ channel at concentrations higher than the therapeutic concentrations of curcumin. Comparing the percent inhibition, the hybrid nanocurcumin limited inhibition to 24.8% at a high curcumin equivalent concentration of 18 ?M. Liposomal curcumin could only decrease this inhibition upto 30% only at lower curcumin concentration of 6 ?M but not at 18 ?M concentration."
According to the news editors, the research concluded: "Here we show a curcumin encapsulated lipopolymeric hybrid nanoparticle formulation which could protect against QT prolongation and also render increased bioavailability and stability thereby overcoming the limitations associated with curcumin."
For more information on this research see: Mitigating prolonged QT interval in cancer nanodrug development for accelerated clinical translation. Journal of Nanobiotechnology, 2013;11():40. (BioMed Central - www.biomedcentral.com/; Journal of Nanobiotechnology - technology.com">www.jnanobiotechnology.com)
The news correspondents report that additional information may be obtained from A.P. Ranjan, Dept. of Molecular Biology & Immunology and Institute for Cancer Research, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, Texas 76107, United States. Additional authors for this research include A. Mukerjee, L. Helson and J.K Vishwanatha (see also Diarylheptanoids).
Keywords for this news article include: Texas, Cancer, Alkanes, Curcumin, Oncology, Catechols, Fort Worth, Hydrocarbons, United States, Diarylheptanoids, Organic Chemicals, North and Central America, Government Agencies Offices and Entities.
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