By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Physical Chemistry. According to news reporting out of San Francisco, California, by NewsRx editors, research stated, "Biological polymers hybridized with single-walled carbon nanotubes (SWCNTs) have elicited much interest recently for applications in SWCNT-based sorting as well as biomedical imaging, sensing, and drug delivery. Recently, de novo designed peptides forming a coiled-coil structure have been engineered to selectively disperse SWCNT of a certain diameter."
Our news journalists obtained a quote from the research from the University of California, "Here, we report on a study of the binding strength and structural stability of the hybrid between such a 'HexCoil-Ala' peptide and the (6,5)-SWCNT. Using the competitive binding of a surfactant, we find that affinity strength of the peptide ranks in comparison to that of two single-stranded DNA sequences as (GT)(30)-DNA > HexCoil-Ala > (TAT)(4)T-DNA. Further, using replica exchange molecular dynamics (REMD), we show that the hexamer peptide complex has both similarities with and differences from the original design. While one of two distinct helix-helix interfaces of the original model was largely retained, a second interface showed much greater variability. These conformational differences allowed an aromatic tyrosine residue designed to lie along the solvent-exposed surface of the protein instead to penetrate between the two helices and directly contact the SWCNT."
According to the news editors, the research concluded: "These insights will inform future designs of SWCNT-interacting peptides."
For more information on this research see: Structural Stability and Binding Strength of a Designed Peptide-Carbon Nanotube Hybrid. Journal of Physical Chemistry C, 2013;117(49):26255-26261. Journal of Physical Chemistry C can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of Physical Chemistry C - www.pubs.acs.org/journal/jpccck)
Our news journalists report that additional information may be obtained by contacting D. Roxbury, University of California, Dept. of Pharmaceut Chem, San Francisco, CA 94143, United States. Additional authors for this research include S.Q. Zhang, J. Mittal, W.F. DeGrado and A. Jagota (see also Physical Chemistry).
Keywords for this news article include: California, Fullerenes, San Francisco, United States, Carbon Nanotubes, Physical Chemistry, North and Central America
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