By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Nanoparticles is the subject of a report. According to news reporting from Magurele, Romania, by NewsRx journalists, research stated, "Phenylboronic-acid-modified nanoparticles (NPs) are attracting considerable attention for biological and biomedical applications. We describe here a convenient and general protocol for attaching multiple copies of para-substituted phenylboronic acid moieties onto either iron-oxide-, silica-or diamond-derived NPs."
The news correspondents obtained a quote from the research from the National Institute of Materials Physics, "The boronic acid fiinctionalized NPs are all fabricated by first modifying the surface of each particle type with 4-azidobenzoic ester functions. These azide-terminated nanostructures were then reacted with 4-[1-ozo-4-pentyn-1-yl) amino]phenylboronic acid units via a Cu(I) catalyzed Huisgen cycloaddition to furnish, conveniently, the corresponding boronic-acid modified NPs (or 'borono-lectins') targeted in this work. The potential of these novel 'borono-lectins' as antiviral inhibitors was investigated against the Hepatitis C virus (HCV) exploiting a bioassay that measures the potential of drugs to interfere with the ability of cell-culture-derived JFH1 virus particles to infect healthy hepatocytes. As far as we are aware, this is the first report that describes NP-derived viral entry inhibitors and thus serves as a 'proof-of-concept' study. The novel viral entry activity demonstrated, and the fact that the described boronic-acid-functionalized NPs all display much reduced cellular toxicities compared with alternate NPs, sets the stage for their further investigation."
According to the news reporters, the research concluded: "The data supports that NP-derived borono-lectins should be pursued as a potential therapeutic strategy for blocking viral entry of HCV."
For more information on this research see: Phenylboronic-Acid-Modified Nanoparticles: Potential Antiviral Therapeutics. ACS Applied Materials & Interfaces, 2013;5(23):12488-12498. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)
Our news journalists report that additional information may be obtained by contacting M. Khanal, Natl Inst Mat Phys, Magurele 077125, Romania. Additional authors for this research include T. Vausselin, A. Barras, O. Bande, K. Turcheniuk, M. Benazza, V. Zaitsev, C.M. Teodorescu, R. Boukherroub, A. Siriwardena, J. Dubuisson and S. Szunerits (see also Nanoparticles).
Keywords for this news article include: Europe, Romania, Magurele, Boronic Acids, Nanotechnology, Boron Compounds, Noncarboxylic Acids, Emerging Technologies
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