By a News Reporter-Staff News Editor at Biotech Week -- New research on Biomedicine and Biomedical Engineering is the subject of a report. According to news reporting originating from Jiangsu, People's Republic of China, by NewsRx correspondents, research stated, "To compare the effects of various recombinant growth factors on bladder regeneration and angiogenesis for tissue engineering of bladder in patients with neurogenic bladder through in vitro cellular biological methods. Human bladder smooth muscle cells (HBSMCs) and human bladder urothelial cells (HBUCs) were cultured from patients with neurogenic bladder and used for comparative evaluations of various growth factors."
Our news editors obtained a quote from the research from Nanjing University, "Human umbilical vein endothelial cells (HUVECs) were also used. Eight potential growth factors, platelet-derived growth factor BB (PDGF-BB), platelet-derived growth factor CC (PDGF-CC), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), insulin-like growth factor 1 (IGF-1), hepatocyte growth factor (HGF), and transforming growth factor beta 1 (TGF-beta 1), were selected and their effects on the proliferation, migration, and wound healing of HBSMCs, HBUCs, and HUVECs were compared. PDGF-BB, PDGF-CC, bFGF, VEGF, IGF-1, or HGF enhanced the proliferation, migration, and wound healing of HBSMCs, whereas TGF-beta 1 inhibited their proliferation. Proliferation, migration, and wound healing of HBUCs and HUVECs were enhanced by bFGF, VEGF, EGF, IGF-1, or HGF, whereas inhibited by TGF-beta 1. PDGF-BB failed to enhance cell activity of HUVECs, whereas PDGF-CC could enhance their migration and wound healing. PDGF-BB, EGF, and VEGF were the most potent factors for stimulating the activities of HBSMCs, HBUCs, and HUVECs, respectively. Our findings suggest the potential use of a combination of PDGF-BB, EGF, and VEGF for bladder regeneration and angiogenesis."
According to the news editors, the research concluded: "The synergetic effects of the three growth factors on cell activities in a three-dimensional scaffold and an animal model with neurogenic bladder need to be further evaluated."
For more information on this research see: In vitro comparative evaluation of recombinant growth factors for tissue engineering of bladder in patients with neurogenic bladder. Journal of Surgical Research, 2014;186(1):63-72. Journal of Surgical Research can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Journal of Surgical Research - www.elsevier.com/wps/product/cws_home/622901)
The news editors report that additional information may be obtained by contacting B. Yang, Nanjing University, Affiliated Drum Tower Hosp, Dept. of Urol, Sch Med, Nanjing 210008, Jiangsu, People's Republic of China. Additional authors for this research include L.H. Zhou, B. Peng, Z.Y. Sun, Y.T. Dai and J.H. Zheng (see also Biomedicine and Biomedical Engineering).
Keywords for this news article include: Asia, VEGF, Tissue Engineering, Biomedicine and Biomedical Engineering, Jiangsu, Bioengineering, Protein Kinases, Membrane Proteins, Angiogenic Proteins, Phosphotransferases, Growth Factor Receptors, Hepatocyte Growth Factor, People's Republic of China, Receptor Protein-Tyrosine Kinases, Vascular Endothelial Growth Factors
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