By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Nanoparticles. According to news reporting from Skopje, Macedonia, by NewsRx journalists, research stated, "Considering the confusing biodistribution data through the literature and few reported alerts as well as our preliminary biodistribution results, we decided to evaluate the interaction and interference of the commonly present Tc-99m (technetium-99m)-stannic oxide colloid during the direct stannous chloride Tc-99m-labeling procedure and to assess its influence on the biodistribution pattern of amphiphilic poly(lactic-co-glycolic acid) nanoparticles. In order to confirm our thesis, beside stannous chloride, we employed two different reducing agents that don't form colloidal particles."
The news correspondents obtained a quote from the research from the Institute of Pathology, "The use of sodium borohydride was previously reported in the literature, whereas sodium dithionite was adapted for the first time in the Tc-99m direct labeling procedure for nanoparticles. The results in our paper clearly differentiate among samples with and without colloidal impurities originating from the labeling procedure with a logical follow up of the radiochemical, physicochemical evaluation, and biodistribution studies clarifying previously reported data on stannic oxide colloidal interference."
According to the news reporters, the research concluded: "Tc-99m-nanoparticle complex labeled with sodium dithionite as reducing agent illustrated appropriate labeling efficacy, stability, and potential for further use in biodistribution studies thus providing solution for the problem of low-complex stability when sodium borohydride is used and colloidal stannic oxide interference for stannous chloride procedure."
For more information on this research see: Comparative biodistribution studies of technetium-99m radiolabeled amphiphilic nanoparticles using three different reducing agents during the labeling procedure. Journal of Labelled Compounds & Radiopharmaceuticals, 2013;56(14):689-695. Journal of Labelled Compounds & Radiopharmaceuticals can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Labelled Compounds & Radiopharmaceuticals - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-1344)
Our news journalists report that additional information may be obtained by contacting N. Geskovski, Univ Ss Cyril & Methodius, Inst Pathol, Fac Med, Skopje 1000, Macedonia. Additional authors for this research include S. Kuzmanovska, M.S. Crcarevska, S. Calis, S. Dimchevska, M. Petrusevska, P. Zdravkovski and K. Goracinova (see also Nanoparticles).
Keywords for this news article include: Skopje, Europe, Anions, Macedonia, Chemicals, Chemistry, Technetium, Nanotechnology, Hydrochloric Acid, Stannous Chloride, Sodium Borohydride, Transition Elements, Radioactive Elements, Emerging Technologies
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC