By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Nanoparticles. According to news reporting out of Potsdam, New York, by NewsRx editors, research stated, "Nanoparticle (NP) exposure may induce oxidative stress through generation of reactive oxygen and nitrogen species, which can lead to cellular and tissue damage. The digestive system is one of the initial organs affected by NP exposure."
Our news journalists obtained a quote from the research from Clarkson University, "Here, it is demonstrated that exposure to metal oxide NPs induces differential changes in zebrafish intestinal NO concentrations. Intestinal NO concentrations are quantified electrochemically with a carbon fiber microelectrode inserted in the intestine of live embryos. Specificity of the electrochemical signals is demonstrated by NO-specific pharmacological manipulations and the results are correlated with the 4,5-diaminofluorescein-diacetate (DAF-FM-DA). NPs are demonstrated to either induce or reduce physiological NO levels depending on their redox reactivity, type and dose. NO level is altered following exposure of zebrafish embryos to CuO and CeO2 NPs at various stages and concentrations. CuO NPs increase NO concentration, suggesting an intestinal oxidative damage. In contrast, low CeO2 NP concentration exposure significantly reduces NO levels, suggesting NO scavenging activity. However, high concentration exposure results in increased NO. Alterations in NO concentration suggest changes in intestinal physiology and oxidative stress, which will ultimately correspond to NPs toxicity."
According to the news editors, the research concluded: "This work also demonstrates the use of electrochemistry to monitor in vivo changes of NO within zebrafish organs."
For more information on this research see: Comparative Evaluation of Intestinal Nitric Oxide in Embryonic Zebrafish Exposed to Metal Oxide Nanoparticles. Small, 2013;9(24):4250-4261. Small can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Small - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-6829)
Our news journalists report that additional information may be obtained by contacting R.E. Ozel, Clarkson University, Dept. of Biol, Potsdam, NY 13699, United States. Additional authors for this research include R.S.J. Alkasir, K. Ray, K.N. Wallace and S. Andreescu (see also Nanoparticles).
Keywords for this news article include: Pharmaceuticals, Drugs, Potsdam, Therapy, New York, Chemicals, Chemistry, Nitric Oxide, United States, Nanotechnology, Nitrogen Oxides, Emerging Technologies, North and Central America, Reactive Nitrogen Species
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