By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Drugs and Therapies have been presented. According to news originating from Mawson Lakes, Australia, by NewsRx correspondents, research stated, "SN38 (7-ethyl-10-hydroxy camptothecin) is a prominent and efficacious anticancer agent. It is poorly soluble in both water and pharmaceutically approved solvents; therefore, the direct formulation of SN38 in solution form is limited."
Our news journalists obtained a quote from the research from the University of South Australia, "Currently, the water soluble prodrug of SN38, irinotecan (CPT-11), is formulated as a low pH solution and is approved for chemotherapy. However, CPT-11, along with most other water-soluble prodrugs shows unpredictable inter-patient conversion to SN38 in vivo, instability in the physiological environment and variable dose-related toxicities. More recently, macromolecular prodrugs (i.e. EZN-2208, IMMU-130) and nanomedicine formulations (i.e. nanoemulsions, polymeric micelles, lipid nanocapsule/nanoparticle, and liposomes) of SN38 have been investigated for improved delivery to cancer cells and tissues. Specifically, these carriers can take advantage of the EPR effect to direct drug preferentially to tumor tissues, thereby substantially improving efficacy and minimising side effects. Furthermore, oral delivery has been shown to be possible in preclinical results using nanomedicine formulations (i.e. dendrimers, lipid nanocapsules, polymeric micelles)."
According to the news editors, the research concluded: "This review summarizes the recent advances for the delivery of SN38 with a focus on macromolecular prodrugs and nanomedicines."
For more information on this research see: Prodrug and nanomedicine approaches for the delivery of the camptothecin analogue SN38. Journal of Controlled Release, 2013;172(1):48-61. (Elsevier - www.elsevier.com; Journal of Controlled Release - www.elsevier.com/wps/product/cws_home/502690)
The news correspondents report that additional information may be obtained from V. Bala, Ian Wark Research Institute, University of South Australia, Mawson Lakes, SA, Australia. Additional authors for this research include S. Rao, B.J. Boyd and C.A Prestidge (see also Drugs and Therapies).
Keywords for this news article include: Mawson Lakes, Camptothecin, Chemotherapy, Drugs and Therapies, Australia and New Zealand.
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