By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Research findings on Age-Related Macular Degeneration are discussed in a new report. According to news originating from Durham, North Carolina, by NewsRx correspondents, research stated, "Describe qualitative spectral-domain optical coherence tomography (SD-OCT) characteristics of eyes classified as intermediate age-related macular degeneration (nonadvanced AMD) from Age-Related Eye Disease Study 2 (AREDS2) color fundus photography (CFP) grading. Prospective cross-sectional study. We included 345 AREDS2 participants from 4 study centers and 122 control participants who lack CFP features of intermediate AMD."
Our news journalists obtained a quote from the research from Duke University, "Both eyes were imaged with SD-OCT and CFP. The SD-OCT macular volume scans were graded for the presence of 5 retinal, 5 subretinal, and 4 drusen characteristics. In all, 314 AREDS2 participants with ?1 category-3 AMD eye and all controls each had 1 eye entered into SD-OCT analysis, with 63 eyes regraded to test reproducibility. We assessed SD-OCT characteristics at baseline. In 98% of AMD eyes, SD-OCT grading of all characteristics was successful, detecting drusen in 99.7%, retinal pigment epithelium (RPE) atrophy/absence in 22.9%, subfoveal geographic atrophy in 2.5%, and fluid in or under the retina in 25.5%. Twenty-eight percent of AMD eyes had characteristics of possible advanced AMD on SD-OCT. Two percent of control eyes had drusen on SD-OCT. Vision loss was not correlated with foveal drusen alone, but with foveal drusen that were associated with other foveal pathology and with overlying focal hyperreflectivity. Focal hyperreflectivity over drusen, drusen cores, and hyper-or hyporeflectivity of drusen were also associated with RPE atrophy. Macular pathologies in AMD can be qualitatively and reproducibly evaluated with SD-OCT, identifying pathologic features that are associated with vision loss, RPE atrophy, and even possibly the presence of advanced AMD not apparent on CFP. Qualitative and detailed SD-OCT analysis can contribute to the anatomic characterization of AMD in clinical studies of vision loss and disease progression."
According to the news editors, the research concluded: "Proprietary or commercial disclosure may be found after the references."
For more information on this research see: Spectral-domain optical coherence tomography characteristics of intermediate age-related macular degeneration. Ophthalmology, 2013;120(1):140-50. (Elsevier - www.elsevier.com; Ophthalmology - www.elsevier.com/wps/product/cws_home/620418)
The news correspondents report that additional information may be obtained from J.N. Leuschen, Duke Eye Center, Durham, North Carolina 27710, United States. Additional authors for this research include S.G. Schuman, K.P. Winter, M.N. McCall, W.T. Wong, E.Y. Chew, T. Hwang, S. Srivastava, N. Sarin, T. Clemons, M. Harrington and C.A Toth (see also Age-Related Macular Degeneration).
Keywords for this news article include: Durham, United States, North Carolina, Retinal Diseases, Imaging Technology, Retinal Degeneration, North and Central America, Optical Coherence Tomography, Age Related Macular Degeneration, Age-Related Macular Degeneration.
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