By a News Reporter-Staff News Editor at Journal of Technology -- Researchers detail new data in Controlled Release Technology. According to news originating from Brussels, Belgium, by VerticalNews correspondents, research stated, "Recently, chitosan has attracted significant attention in the formulation of small interfering RNA (siRNA). Because of its cationic nature, chitosan can easily complex siRNA, thus readily forming nanoparticles."
Our news journalists obtained a quote from the research from Louvain Drug Research Institute, "Moreover, chitosan is biocompatible and biodegradable, which make it a good candidate for siRNA delivery in vivo. However, chitosan requires further development to achieve high efficiency. This review will describe the major barriers that impair the efficiency of the chitosan-based siRNA delivery systems, including the stability of the delivery system in biological fluids and endosomal escape. Several solutions to counteract these barriers have been developed and will be discussed. The parameters to consider for designing powerful delivery systems will be described, particularly the possibilities for grafting targeting ligands. Finally, optimized systems that allow in vivo therapeutic applications for both local and systemic delivery will be reviewed."
According to the news editors, the research concluded: "This review will present recent improvements in chitosan-based siRNA delivery systems that overcome many of these system's previous pitfalls and pave the way to a new generation of siRNA delivery systems."
For more information on this research see: Chitosan-based siRNA delivery systems. Journal of Controlled Release, 2013;172(1):207-18. (Elsevier - www.elsevier.com; Journal of Controlled Release - www.elsevier.com/wps/product/cws_home/502690)
The news correspondents report that additional information may be obtained from H. Ragelle, Pharmaceutics and Drug Delivery Group, Louvain Drug Research Institute, Universite Catholique de Louvain, 1200 Brussels, Belgium. Additional authors for this research include G. Vandermeulen and V. Preat.
Keywords for this news article include: Europe, Belgium, Brussels, Controlled Release Technology.
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