The news reporters obtained a quote from the research from the Faculty of Pharmacy, "The capability of these compounds to form stable nanoparticles with plasmid DNA has been demonstrated by gel electrophoresis, transmission electron microscopy (TEM), and dynamic light scattering (DLS) investigations. Transfection efficiencies of the self-assembled 13/pCMV-Luc and 14/pCMV-Luc polyplexes have been evaluated in vitro with HeLa cells."
According to the news reporters, the research concluded: "The transfection efficiencies found for both compounds are good, and pillararenes 13 and 14 show very low toxicity if any."
For more information on this research see: Polycationic Pillararene Derivatives: Interaction with DNA and Biological Applications.
Our news correspondents report that additional information may be obtained by contacting I. Nierengarten, Fac Pharm, CNRS UMR 7199, F-67401 Illkirch Graffenstaden,
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Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC
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