Our news journalists obtained a quote from the research, "The chemical-physical features of the nanoparticles are fully investigated and their interaction with cells expressing (GTL-16 gastric carcinoma line) or not expressing (NIH-3T3 fibroblasts) the Met/HGFR is analyzed. Functionalized nanoparticles specifically bind to and are internalized in cells expressing the receptor (GTL-16) but not in the ones that do not express it (NIH-3T3). Moreover they discharge DOXO in the targeted GTL-16 cells that reach the nucleus and display cytotoxicity as assessed in an MTT assay. Two different types of ternary nanoparticles are prepared, differing for the sequence of the functionalization steps (adsorption of DOXO first and then mAb or vice versa), and it is found that the ones in which mAb is adsorbed first are more efficient under all the examined aspects (binding, internalization, cytotoxicity), possibly because of a better mAb orientation on the nanoparticle surface. These multifunctional nanoparticles could thus be useful instruments for targeted local or systemic drug delivery, allowing a reduction in the therapeutic dose of the drug and thus adverse side effects."
According to the news editors, the research concluded: "Moreover, this work opens new perspectives in the use of nanocrystalline apatites as a new platform for theranostic applications in nanomedicine."
For more information on this research see: Cell surface receptor targeted biomimetic apatite nanocrystals for cancer therapy. Small, 2013;9(22):3834-44. (Wiley-Blackwell - www.wiley.com/; Small - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-6829)
Our news journalists report that additional information may be obtained by contacting M. Iafisco, Universita del Piemonte Orientale, Dipartimento di Scienze della Salute, Via Solaroli 17, 28100
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