By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Nanostructures. According to news reporting from Seoul, South Korea, by NewsRx journalists, research stated, "Toroidal nanostructures are symmetrical ring-shaped structures with a central internal pore. Interestingly, in nature, many transmembrane proteins such as beta-barrels and alpha-helical bundles have toroidal shapes."
The news correspondents obtained a quote from the research from Seoul National University, "Because of this similarity, toroidal nanostructures can provide a template for the development of transmembrane channels. However, because of the lack of guiding principles for the construction of toroids, researchers have not widely studied the self-assembly of toroidal nanostructures as compared with the work on other supramolecular architectures. In this Account, we describe our recent efforts to construct toroidal nanostructures through the self-assembly of rationally designed building blocks. In one strategy for building these structures, we induce interfacial curvatures within the building blocks. When we laterally graft a bulky hydrophilic segment onto a p-oligophenyl rod or beta-sheet peptides, the backbones of the self-assembled structures can bend in response to the steric effect of these large side groups, driving the p-oligophenyl rod or beta-sheet peptides to form nanosized toriods. In another strategy, we can build toroids from bent-shaped building blocks by stacking the macrocycles. Aromatic segments with an internal angle of 120 degrees can associate with each other in aqueous solution to form a hexameric macrocycle. Then these macrocycles can stack on top of each other via hydrophobic and pi-pi interactions and form highly uniform toroidal nanostructures. We provide many examples that illustrate these guiding principles for constructing toroidal nanostructures in aqueous solution. Efforts to create toroidal nanostructures through the self-assembly of elaborately designed molecular modules provide a fundamental approach toward the development of artificial transmembrane channels."
According to the news reporters, the research concluded: "Among the various toroids that we developed, a few nanostructures can insert into lipid membranes and allow limited transport in vesicles."
For more information on this research see: Development of Toroidal Nanostructures by Self-Assembly: Rational Designs and Applications. Accounts of Chemical Research, 2013;46(12):2888-2897. Accounts of Chemical Research can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Accounts of Chemical Research - www.pubs.acs.org/journal/achre4)
Our news journalists report that additional information may be obtained by contacting Y. Kim, Seoul National University, Dept. of Chem, Seoul 151747, South Korea. Additional authors for this research include W. Li, S. Shin and M. Lee (see also Nanostructures).
Keywords for this news article include: Asia, Seoul, South Korea, Nanostructural, Nanostructures, Nanotechnology, Emerging Technologies
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