By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in Indicators and Reagents. According to news reporting originating in Seoul, South Korea, by NewsRx journalists, research stated, "Bases such as potassium carbonate and potassium bicarbonate (KHCO3) are essential for the elution of trapped [F-18]fluoride from ion exchange cartridges and for the prevention of [F-18]fluoride adsorption on the silica glass vial during the preparation of radiopharmaceuticals for positron emission tomography imaging. However, these bases promote the chemical decomposition of precursor compounds and the creation of unwanted organic impurities."
The news reporters obtained a quote from the research from Dongguk University, "Thus, the goal of the current study was to develop a new method for synthesizing [F-18]fluoride-labeled radiopharmaceuticals (e.g., [F-18]fluoromisonizadole ([F-18]FMISO)) that permits the fine control of base concentrations while minimizing adverse events. Non-decay-corrected radiochemical yields of 25.1 +/- 5.0% and 13.3 +/- 5.1% (n=3) were achieved after solid-phase extraction purification using automatic synthesis with GE TRACERlab MX and KHCO3 at concentrations of 14.1 and 33.0 mu mol, respectively, and 1mg of precursor (1-(2-nitro-1-imidazolyl)-2-O-tetra-hydropyranyl-3-O-toluenesulfonyl propanediol (NITTP))."
According to the news reporters, the research concluded: "The newly developed synthesis protocol with fine base control and low precursor content permits high radiochemical yields with minimal impurities."
For more information on this research see: Development of a new precursor-minimizing base control method and its application for the automated synthesis and SPE purification of [F-18]fluoromisonidazole ([F-18]FMISO). Journal of Labelled Compounds & Radiopharmaceuticals, 2013;56(14):731-735. Journal of Labelled Compounds & Radiopharmaceuticals can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Labelled Compounds & Radiopharmaceuticals - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-1344)
Our news correspondents report that additional information may be obtained by contacting S.J. Lee, Dongguk Univ, Dept. of Chem, Seoul, South Korea. Additional authors for this research include J.S. Hyun, S.J. Oh, K.H. Yu and J.S. Ryu (see also Indicators and Reagents).
Keywords for this news article include: Asia, Seoul, Anions, Fluorides, South Korea, Hydrofluoric Acid, Indicators and Reagents
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