By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Biotechnology. According to news reporting originating in Chicago, Illinois, by NewsRx journalists, research stated, "Emerging and reemerging human viral pathogens pose great public health concerns since therapeutics against these viruses are limited. Thus, there is an urgent need to develop novel drugs that can block infection of either a specific virus or a number of viruses."
The news reporters obtained a quote from the research from the University of Illinois, "Viral entry is thought to be an ideal target for potential therapeutic prevention. One of the challenges of developing antivirals is that most of these viruses are highly pathogenic and therefore require high biosafety-level containment. In this study, we have adopted a comparative high-throughput screening protocol to identify entry inhibitors for three enveloped viruses (Marburg virus, influenza virus H5N1, and Lassa virus) using a human immunodeficiency virus-based pseudotyping platform. We demonstrate the utility of this approach by screening a small compound library and identifying putative entry inhibitors for these viruses."
According to the news reporters, the research concluded: "One major advantage of this protocol is to reduce the number of false positives in hit selection, and we believe that the protocol is useful for inhibitor screening for many enveloped viruses."
For more information on this research see: A Comparative High-Throughput Screening Protocol to Identify Entry Inhibitors of Enveloped Viruses. Journal of Biomolecular Screening, 2014;19(1):100-107. Journal of Biomolecular Screening can be contacted at: Sage Publications Inc, 2455 Teller Rd, Thousand Oaks, CA 91320, USA. (Sage Publications - www.sagepub.com/; Journal of Biomolecular Screening - jbx.sagepub.com)
Our news correspondents report that additional information may be obtained by contacting J. Wang, University of Illinois, High Throughput Screening Facil, Chicago, IL 60612, United States. Additional authors for this research include H. Cheng, K. Ratia, E. Varhegyi, W.G. Hendrickson, J. Li and L.J. Rong (see also technology.html">Biotechnology).
Keywords for this news article include: Biotechnology, Chicago, Viruses, Illinois, Virology, Therapeutics, United States, North and Central America
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