By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Oncology are discussed in a new report. According to news reporting originating from Yangsan, South Korea, by NewsRx correspondents, research stated, "The integration of unique functionality into mesoporous organosilica hybrid carriers is an important issue in solving the challenges of dual/multi delivery for combined therapy with drugs with a distinct therapeutic effects. Newly designed mesoporous organosilica hybrid microcarriers (HMCs)are synthesized on the basis of the triblock-copolymer-templated sol-gel method."
Our news editors obtained a quote from the research from Pusan National University, "The synthesized HMCs, whichintegrate both heteroaromatic pyridine and diurea functionalities, are combined in a mesoporous organosilica hybrid network to design functional hybrid microcarriers with a range of mechanisms for the pH-triggered release of two drugs. The drugs include the hydrophilic anticancer therapeutic agent 5-fluorouracil (5-FU) and the non-steroidal hydrophobic anti-inflammatory drug ibuprofen (IBU). 5-FU and IBU are encapsulated in the HMCs using multiple hydrogen bonding and electrostatic interaction sites and are delivered under a range of pH conditions. The release of 5-FU and IBU is tested at pH 5.5 and 7.4. The results show that the release is sensitive to pH. The antitumor activity of the released 5-FU is evaluated using the MCF-7 cell line."
According to the news editors, the research concluded: "The released 5-FU has the capacity to kill cancer cells under acidic pH conditions."
For more information on this research see: Design of a Novel Mesoporous Organosilica Hybrid Microcarrier: a pH Stimuli-Responsive Dual-Drug-Delivery Vehicle for Intracellular Delivery of Anticancer Agents. Particle & Particle Systems Characterization, 2013;30(12):1044-1055. Particle & Particle Systems Characterization can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Particle & Particle Systems Characterization - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-4117)
The news editors report that additional information may be obtained by contacting M.S. Moorthy, Pusan National University, Dept. of Biochem, Sch Med, Yangsan 626870, South Korea. Additional authors for this research include J.H. Bae, M.J. Kim, S.H. Kim and C.S. Ha (see also Oncology).
Keywords for this news article include: Asia, Yangsan, Therapy, Oncology, South Korea, Organosilica, Nanotechnology, Drug Delivery Systems, Emerging Technologies
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