By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Indicators and Reagents. According to news reporting originating from Izmir, Turkey, by NewsRx correspondents, research stated, "In this study, N-methacryloyl-l-phenylalanine (MAPA) containing poly(2-hydroxyethylmethacrylate) (HEMA)-based magnetic poly(HEMA-MAPA) nanobeads [mag-poly(HEMA-MAPA)] were radiolabeled with I-131 [I-131-mag-poly(HEMA-MAPA)], and the radiopharmaceutical potential of I-131-mag-poly(HEMA-MAPA) was investigated. Quality control studies were carried out by radiochromatographic method to be sure that I-131 binded to mag-poly(HEMA-MAPA) efficiently."
Our news editors obtained a quote from the research from the University of Ege, "In this sense, binding yield of I-131-mag-poly(HEMA-MAPA) was found to be about 95-100%. In addition to this, optimum radiodination conditions for I-131-mag-poly(HEMA-MAPA) were determined by thin-layer radiochromatography studies. In addition to thin-layer radiochromatography studies, lipophilicity (partition coefficient) and stability studies for I-131-mag-poly(HEMA-MAPA) were realized. It was determined that lipophilicities of mag-poly(HEMA-MAPA) and I-131-mag-poly(HEMA-MAPA) were 0.12 +/- 0.01 and 1.79 +/- 0.76 according to ACD/logP algorithm program, respectively. Stability of the radiolabeled compound was investigated in time intervals given as 0, 30, 60, 180, and 1440min. It was found that I-131-mag-poly(HEMA-MAPA) existed as a stable complex in rat serum within 60min. After that, biodistribution and scintigraphy studies were carried out by using albino Wistar rats. It was determined that the most important I-131 activity uptake was observed in the breast, the ovary, and the pancreas."
According to the news editors, the research concluded: "Scintigraphy studies well supported biodistribution results."
For more information on this research see: Radiolabeling of new generation magnetic poly(HEMA-MAPA) nanoparticles with I-131 and preliminary investigation of its radiopharmaceutical potential using albino Wistar rats. Journal of Labelled Compounds & Radiopharmaceuticals, 2013;56(14):708-716. Journal of Labelled Compounds & Radiopharmaceuticals can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Labelled Compounds & Radiopharmaceuticals - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-1344)
The news editors report that additional information may be obtained by contacting U. Avcibasi, Ege University, Ege Higher Vocat Sch, TR-35100 Izmir, Turkey. Additional authors for this research include H. Demiroglu, M. Ediz, H.A. Akalin, E. Ozcaliskan, H. Senay, C. Turkcan, Y. Ozcan, S. Akgol and N. Avcibasi (see also Indicators and Reagents).
Keywords for this news article include: Izmir, Turkey, Eurasia, Nanoparticle, Nanotechnology, Radiopharmaceuticals, Emerging Technologies, Indicators and Reagents
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