By a News Reporter-Staff News Editor at Pharma Business Week -- A new study on Drugs and Therapies is now available. According to news reporting out of Cambridge, United Kingdom, by NewsRx editors, research stated, "Full-field optical coherence tomography (FF-OCT) using a conventional light-emitting diode and a complementary metal-oxide semiconductor camera has been developed for characterising coatings on small pellet samples. A set of en-face images covering an area of 700 x 700 m(2) was taken over a depth range of 166 m. The three-dimensional structural information, such as the coating thickness and uniformity, was subsequently obtained by analysis of the recorded en-face images."
Our news journalists obtained a quote from the research from the University of Cambridge, "Drug-loaded pharmaceutical sustained-release pellets with two coating layers and of a sub-millimetre diameter were studied to demonstrate the usefulness of the developed system. We have shown that both coatings can be clearly resolved and the thickness was determined to be 40 and 50 m for the outer and inner coating layers, respectively. It was also found that the outer coating layer is relatively uniform, whereas the inner coating layer has many particle-like features. X-ray computed microtomography measurements carried out on the same pellet sample confirmed all these findings."
According to the news editors, the research concluded: "The presented FF-OCT approach is inexpensive and has better spatial resolution compared with other non-destructive analysis techniques such as terahertz pulsed imaging, and is thus considered advantageous for the quantitative analysis of thin coatings on small pellet samples."
For more information on this research see: Non-Destructive Evaluation of Polymer Coating Structures on Pharmaceutical Pellets Using Full-Field Optical Coherence Tomography. Journal of Pharmaceutical Sciences, 2014;103(1):161-166. Journal of Pharmaceutical Sciences can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Pharmaceutical Sciences - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1520-6017)
Our news journalists report that additional information may be obtained by contacting C. Li, University of Cambridge, Dept. of Chem Engn & Biotechnol, Cambridge CB2 3RA, United Kingdom. Additional authors for this research include J.A. Zeitler, Y. Dong and Y.C. Shen (see also Drugs and Therapies).
Keywords for this news article include: Europe, Cambridge, United Kingdom, Imaging Technology, Drugs and Therapies, Optical Coherence Tomography
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