The first paper entitled, "Evaluation of Long-Term Treatment Effect in a Type 1 Diabetes Intervention Trial: Differences after Stimulation with Glucagon or a Mixed-Meal" by Pozzilli et al, discusses new data comparing the results of different methods of stimulation of C-peptide, used as a marker for insulin secretion by pancreatic beta cells. The two methods of stimulation, glucagon (GST) and mixed-meal (MMTT), used in the DIA-AID 1 study to evaluate beta cell function were compared regarding their ability to measure long-term changes in C-peptide secretion. The analysis presented in the article demonstrates that the different stimuli measure different outcomes and that it is important to consider these differences in evaluating changes in insulin secretion in newly diagnosed type 1 diabetes patients. The article can be found online at http://care.diabetesjournals.org/content/early/2014/01/02/dc13-1392.abstract?papetoc.
The second paper entitled, "Treatment of Recent Onset Type 1 Diabetes Patients with DiaPep277®: Results of a Double-Blind, Placebo-Controlled, Randomized Phase 3 Trial" by Raz et al, describes clinical data from 457 newly diagnosed type 1 diabetes patients who participated in DIA-AID 1, a phase 3 study evaluating the safety and efficacy of DiaPep277®.
The results show significant preservation of insulin secreting cells in patients treated with DiaPep277® compared to the placebo arm, treatment effect of 23.4% (p=0.037). The study also demonstrated that a greater proportion of DiaPep277® treated patients maintained good diabetic control compared to the placebo (measured by HbA1c equal or less than 7% at the end of the study), had a lower rate of hypoglycemic events and achieved partial remission. Safety data indicate that DiaPep277® was well tolerated. No major differences in drug-related adverse events were reported between the treatment and placebo groups.
DiaPep277®, a unique peptide of 24 amino acids derived from the sequence of the human heat shock protein 60 (Hsp60), was invented by Prof Irun Cohen and his team at the
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