“Acetylon has emerged from one of the most difficult periods for raising funds for biotech startups in the history of the industry,” said FierceBiotech Editor
The Fierce 15 celebrates the spirit of being "fierce" – championing innovation and creativity, even in the face of intense competition. This is FierceBiotech's eleventh annual Fierce 15 selection.
“We are delighted to be selected as part of this year’s ‘Fierce 15’, an award that honors our employees, founders, and academic and clinical collaborators for the tremendous work they have done in realizing the immense therapeutic potential for next-generation, selective HDAC inhibitors, including our lead drug candidate ACY-1215 for the treatment of hematological malignancies including multiple myeloma,” commented
Acetylon is developing a portfolio of oral, selective HDAC inhibitors in oncology, hematology, immunology and neurologic disease. The Company’s lead candidate, ACY-1215, is an oral HDAC6 inhibitor currently in two clinical trials for the treatment of relapsed or refractory multiple myeloma: a Phase 1/2 trial in combination with first-in-class drug Velcade® (bortezomib) and a Phase 1b trial in combination with best-in-class drug Revlimid® (lenalidomide), which have reported early evidence of a favorable safety profile for ACY-1215 as well as extensive clinical responses in patients with advanced disease. In addition, Acetylon is developing a further highly selective HDAC6 inhibitor for neurodgenerative diseases, an HDAC1/2 inhibitor for sickle cell disease and beta-thalassemia, and a yet unnamed project – spanning a broad range of cancer and non-cancer disease indications.
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