By a News Reporter-Staff News Editor at Science Letter -- Fresh data on Chromatography are presented in a new report. According to news originating from Montpellier, France, by NewsRx correspondents, research stated, "Environmental field studies have shown that carbamazepine (Cbz) is one of the most frequently detected human pharmaceuticals in different aquatic compartments. However, little data is available on the detection of this substance and its transformation products in aquatic organisms."
Our news journalists obtained a quote from the research from the University of Montpellier I, "This study was thus mainly carried out to optimize and validate a simple and sensitive analytical methodology for the detection, characterization and quantification of Cbz and oxcarbazepine (Ox), two anticonvulsants, and six of their main transformation products in marine mussels (Mytilus galloprovincialis). A modified QuEChERS extraction method followed by analysis with liquid chromatography coupled to high resolution mass spectrometry (HRMS) was used. The analyses were performed using two-stage fragmentation to reveal the different fragmentation pathways that are highly useful for the identification of isomeric compounds, a common problem when several transformation products are analyzed. The developed analytical method allowed determination of the target analytes in the lower ng/g concentration levels. The mean recovery ranged from 67 to 110%. The relative standard deviation was under 11% in the intra-day and 18% in the interday analyses, respectively. Finally, the method was applied to marine mussel samples collected from Mediterranean Sea cultures in southeastern France. Residues of the psychiatric drug Cbz were occasionally found at levels up to 3.5 ng/g dw."
According to the news editors, the research concluded: "Lastly, in this study, other non-target compounds, such as caffeine, metoprolol, cotinine and ketoprofen, were identified in the real samples analyzed."
For more information on this research see: Fast and easy extraction combined with high resolution-mass spectrometry for residue analysis of two anticonvulsants and their transformation products in marine mussels. Journal of Chromatography A, 2013;1305():27-34. Journal of Chromatography A can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Chromatography A - www.elsevier.com/wps/product/cws_home/502688)
The news correspondents report that additional information may be obtained from M.J.M. Bueno, Univ Montpellier I, Hydrosci Montpellier UMR 5569, Dept. of Environm Sci & Public Hlth, F-34000 Montpellier, France. Additional authors for this research include C. Boillot, H. Fenet, S. Chiron, C. Casellas and E. Gomez (see also Chromatography).
Keywords for this news article include: France, Europe, Montpellier, Chromatography
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