technology Study Findings from Drexel University -->
By a News Reporter-Staff News Editor at Science Letter -- Research findings on Nanotechnology are discussed in a new report. According to news originating from Philadelphia, Pennsylvania, by NewsRx correspondents, research stated, "The lipid arrangement of eukaryotic cell membranes has been shown to be heterogeneous, with domains enriched in cholesterol and saturated phospholipids, coexisting with a continuous phase that is enriched in unsaturated phospholipids. While the existence of these domains is well-established, there is still a lack of consensus regarding domain size and the factors influencing it."
Our news journalists obtained a quote from the research from Drexel University, "In this work, we investigate model membranes consisting of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)-1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) cholesterol (Chol) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC, 18:1-16:0) DSPC Chol with a steady-state fluorescence assay and report the influence of phospholipid chain saturation and chain length on domain size. The spectral shifts of 1-myristoyl-2-[12-[(5-dimethylamino-1-naphthalenesulfonyl)amino]-dodecanoyl]-sn-glycero-3-phosphocholine (DAN-PC) and a Forster resonance energy transfer (FRET) assay were used, along with an analytical model, to estimate domain sizes. A region of nanoscale domain existence was observed in both ternary systems; however, the domains formed in the system containing the asymmetric lipid (POPC, 18:1-16:0) were larger than those formed in the diunsaturated lipid (DOPC, 18:1-18:1)."
According to the news editors, the research concluded: "This is a new finding, as domains were not previously known to exist in similar POPC-based systems."
For more information on this research see: Nanoscale Phase Separation in DSPC-Cholesterol Systems. Langmuir, 2013;29(31):9832-9840. Langmuir can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Langmuir - www.pubs.acs.org/journal/langd5)
The news correspondents report that additional information may be obtained from A.C. Brown, Drexel University, Dept. of Chem & Biol Engn, Philadelphia, PA 19104, United States (see also technology.html">Nanotechnology).
Keywords for this news article include: Nanoscale, Philadelphia, Pennsylvania, United States, Nanotechnology, Emerging Technologies, North and Central America
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