By a News Reporter-Staff News Editor at Science Letter -- Investigators publish new report on Polyethylenes. According to news reporting from Wuhan, People's Republic of China, by NewsRx journalists, research stated, "Multidrug resistance (MDR) is one of the major obstacles to successful chemotherapy. Overexpression of drug efflux transporters such as P-glycoprotein (P-gp) is an important factor responsible for MDR."
The news correspondents obtained a quote from the research from the Huazhong University of Science and Technology, "Herein, a novel copolymer, D-alpha-tocopheryl polyethylene glycol 1000-block-poly-(beta-amino ester) (TPGS-b-PBAE, TP), was synthesized for overcoming multidrug resistance by the synergistic effect of the pH-sensitive behavior of PBAE and P-gp inhibiting activity of TPGS. Docetaxel (DTX) was chosen as the model drug. The resulting DTX-loaded nanoparticles were stable at pH 7.4, while they dissociated in a weakly acidic environment (pH 5.5) and released the incorporated DTX quickly. The DTX-loaded TP nanoparticles increased the cell cytotoxicity against both drug-sensitive human ovarian A2780 and drug-resistant A2780/T cells. The IC50 of DTX-loaded TP against A2780/T cells was 100-fold lower than that of commercial DTX. This was associated with enhanced DTX-induced apoptosis and cell arrest in the G2/M phase. Furthermore, P-gp inhibition assays, including enhancement of the fluorescence intensity of rhodamine 123 and reduction of the intracellular ATP levels, confirmed the P-gp inhibition nature of the TP copolymer."
According to the news reporters, the research concluded: "The use of the TP copolymer is a new approach to improve the therapeutic effect of anticancer drugs in MDR tumors."
For more information on this research see: pH-Sensitive Docetaxel-Loaded D-alpha-Tocopheryl Polyethylene Glycol Succinate-Poly(beta-amino ester) Copolymer Nanoparticles for Overcoming Multidrug Resistance. Biomacromolecules, 2013;14(8):2636-2646. Biomacromolecules can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Biomacromolecules - www.pubs.acs.org/journal/bomaf6)
Our news journalists report that additional information may be obtained by contacting S. Zhao, Huazhong University of Science & Technology, Natl Engn Res Center Nanomed, Wuhan 430030, People's Republic of China. Additional authors for this research include S.W. Tan, Y.Y. Guo, J. Huang, M. Chu, H.D. Liu and Z.P. Zhang (see also Polyethylenes).
Keywords for this news article include: Asia, Wuhan, Alkenes, Polyenes, Succinates, Hydrocarbons, Nanoparticle, Therapeutics, Nanotechnology, Succinic Acids, Organic Chemicals, Dicarboxylic Acids, Polyethylene Glycols, Emerging Technologies, People's Republic of China
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