By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Tropanes. According to news reporting originating from Gyeongju, South Korea, by NewsRx correspondents, research stated, "To study the chemical constituents of Zhizi (Fructus Gardeniae) and their antiamnesic effect in a mouse model of Alzheimer's disease. Ameliorating effects of the extracts, fractions and constituents on scopolamine-induced memory impairment in vivo using a passive avoidance task system and their inhibitory activities on acetylcholinesterase (AChE) in vitro were examined."
Our news editors obtained a quote from the research from Dongguk University, "The isolation of components was performed by chromatographic techniques and their structures were identified on the basis of spectral analysis. Activity-guided fractionation of the total extracts resulted in the isolation of two glycosides, geniposide and crocin from the n-butanol fraction and genipin and crocetin from the ethylacetate fraction. Among the fractions tested, n-butanol fraction showed the strongest AChE inhibition (43.4% at a final dose of 0.03 mg/mL) and also exhibited outstanding efficacy (65.9% at a dose of 250 mg/kg) in an experimental model of amnesia. Geniposide showed a 22.8% AChE inhibitory activity and a potent ameliorating effect on scopolamine-induced memory impairment in amnesic mice of 93.4% as compared to the control group."
According to the news editors, the research concluded: "Geniposide, a main constituent of gardenia should be considered a candidate for further clinical study for the purpose of developing a cognition activator and its mechanism of action may be mediated, at least in part, by the acetylcholine enhancing cholinergic nervous system."
For more information on this research see: Ameliorating effect of zhizi (Fructus gardeniae) extract and its glycosides on scopolamine-induced memory impairment. Journal of Traditional Chinese Medicine, 2013;33(2):223-7. (Elsevier - www.elsevier.com; Journal of Traditional Chinese Medicine - www.elsevier.com/wps/product/cws_home/715026)
The news editors report that additional information may be obtained by contacting Y. Nam, Division of Bioscience, Dongguk University, Gyeongju 780-714, South Korea (see also Tropanes).
Keywords for this news article include: Asia, Gyeongju, Tropanes, South Korea, Scopolamine.
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