technology Are Outlined in Reports from University of Hamburg -->
By a News Reporter-Staff News Editor at Biotech Week -- New research on Biotechnology is the subject of a report. According to news reporting out of Hamburg, Germany, by NewsRx editors, research stated, "Poly(ethylene glycol)- (PEG-) based ligands are well-established for the stabilization of nanoparticles in aqueous solution and are especially interesting for applications in medicine and biotechnology because they are known to improve the pharmacokinetic properties of nanomaterials. In this study, we prepared gold nanoparticles (AuNPs) with ligand shells of different monodentate poly(ethylene glycol)-thiol (PEG-SH) ligands."
Our news journalists obtained a quote from the research from the University of Hamburg, "These ligands differed only in the segment connecting the thiol group with the PEG moiety (M-w approximate to 2000 g/mol) through an ester bond, the spacer. All ligands were synthesized by straightforward esterification. Specifically, we used PEG ligands with a long (C-10, PEGMUA) or short (C-2, PEGMPA) alkylene spacer or a phenylene (PEGMPAA) spacer. The influence of the spacer on the stability of gold nanoparticle PEG conjugates (AuNP@PEG) was tested by cyanide etching experiments, electrolyte-induced aggregation, and competitive ligand displacement with dithiothreitol (DTT). In the presence of 100 mM cyanide, AuNPs stabilized with PEGMPA or PEGMPAA were completely dissolved by oxidative etching within a few minutes, whereas AuNPs stabilized with PEGMUA needed more than 20 h to be completely etched. By complementary experiments, we deduced a simplified description for the etching process that takes into account the role of excess ligand. In the presence of free ligand, significantly fewer AuNPs are etched, suggesting a competition of etching and ligand binding to AuNPs. We also compared the stabilizing effect of PEGMUA with that of a bidentate PEG-thiol ligand (PEGLIP) and found a reversed stability against cyanide etching and DTT displacement, in agreement with previously reported observations."
According to the news editors, the research concluded: "Our results clearly demonstrate the strong impact of the spacer structure on conjugate stability and provide valuable information for the rational design of more complex AuNP@PEG conjugates, which are of much interest in the context of biotechnology and medical applications."
For more information on this research see: Effect of the Spacer Structure on the Stability of Gold Nanoparticles Functionalized with Monodentate Thiolated Poly(ethylene glycol) Ligands. Langmuir, 2013;29(31):9897-9908. Langmuir can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Langmuir - www.pubs.acs.org/journal/langd5)
Our news journalists report that additional information may be obtained by contacting F. Schulz, University of Hamburg, Inst Phys Chem, D-20146 Hamburg, Germany. Additional authors for this research include T. Vossmeyer, N.G. Bastus and H. Weller (see also technology.html">Biotechnology).
Keywords for this news article include: Biotechnology, Europe, Hamburg, Germany, Alkenes, Nanotechnology, Ethylene Glycols, Gold Nanoparticles, Emerging Technologies
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