Our news journalists obtained a quote from the research, "Nowadays, ligand-binding assays can determine every aspect of many drug-target interactions. Given that ligand-target interactions are very diverse, the author has decided to focus on the binding of small molecules to protein targets. This article first reviews the key biochemical aspects of drug-target interactions, and then discusses the detection principles of various ligand-binding techniques in the context of their primary applications for drug discovery and development. Equilibrium-binding affinity should not be used as a solo indicator for the in vivo pharmacology of drugs. The clinical relevance of drug-binding kinetics demands high throughput kinetics early in drug discovery. The dependence of ligand binding and function on the conformation of targets necessitates solution-based and whole cell-based ligand-binding assays. The increasing need to examine ligand binding at the proteome level, driven by the clinical importance of the polypharmacology of ligands, has started to make the structure-based in silico binding screen an indispensable technique for drug discovery and development."
According to the news editors, the research concluded: "Integration of different ligand-binding assays is important to improve the efficiency of the drug discovery and development process."
For more information on this research see: Ligand-receptor interaction platforms and their applications for drug discovery. Expert Opinion On Drug Discovery, 2012;7(10):969-88 (see also Drug Development).
Our news journalists report that additional information may be obtained by contacting Y. Fang, Biochemical Technologies, Science and Technology Division,
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