By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Current study results on Nervous System Diseases and Conditions have been published. According to news reporting out of Boston, Massachusetts, by NewsRx editors, research stated, "Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease characterized by progressive degeneration of the motor neurons in the cortex, brainstem, and spinal cord. The etiology and mechanisms of selective motor neuron loss in ALS remain unknown."
Our news journalists obtained a quote from the research from Harvard University, "Wnt signaling is involved in neurodegenerative processes but little is known about the kinetic changes in Wnt signaling during ALS progression. In this study we used transcriptional microarray analysis to examine the expression of Wnt signaling components in the spinal cords of ALS transgenic SOD1(G93A) mice at different stages. We found that ALS onset led to the upregulation of Wnt signaling components and target genes involved in growth regulation and proliferation. We also determined the expression of Wnt inhibitory factor-1 (Wif1) and Wnt4 in the spinal cord of ALS transgenic mice at different stages by Western blot and immunofluorescence analysis. The protein levels of Wif1 and Wnt4 in the spinal cords of ALS transgenic mice were upregulated compared to those in wild-type mice. Moreover, the expression of Wif1 and Wnt4 in mature GFAP+ astrocytes was increased at the end stage of ALS."
According to the news editors, the research concluded: "Our findings demonstrate that Wnt signaling is altered by spinal cord neuronal dysfunction in adult ALS transgenic mice, which provides new insight into ALS pathogenesis."
For more information on this research see: Wnt Signaling is Altered by Spinal Cord Neuronal Dysfunction in Amyotrophic Lateral Sclerosis Transgenic Mice. Neurochemical Research, 2013;38(9):1904-1913. Neurochemical Research can be contacted at: Springer, Plenum Publishers, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Neurochemical Research - www.springerlink.com/content/0364-3190/)
Our news journalists report that additional information may be obtained by contacting L. Yu, Harvard University, Sch Med, Brigham & Women's Hospital, Dept. of Neurosurg, Boston, MA 02115, United States. Additional authors for this research include Y.J. Guan, X. Wu, Y.C. Chen, Z.J. Liu, H.M. Du and X. Wang (see also Nervous System Diseases and Conditions).
Keywords for this news article include: Boston, Genetics, Neurology, Massachusetts, United States, Motor Neuron Disease, Spinal Cord Diseases, Neuromuscular Diseases, TDP-43 Proteinopathies, North and Central America, Proteostasis Deficiencies, Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis, Central Nervous System Diseases
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