By a News Reporter-Staff News Editor at Gene Therapy Weekly -- A new study on Neuropathy is now available. According to news reporting originating in Atlanta, Georgia, by NewsRx editors, the research stated, "The hereditary optic neuropathies are inherited disorders in which optic nerve dysfunction is a prominent feature in the phenotypic expression of disease. Optic neuropathy may be primarily an isolated finding, such as in Leber hereditary optic neuropathy and dominant optic atrophy, or part of a multisystem disorder."
The news reporters obtained a quote from the research from the Emory University School of Medicine, "The pathophysiological mechanisms underlying the hereditary optic neuropathies involve mitochondrial dysfunction owing to mutations in mitochondrial or nuclear DNA that encodes proteins essential to mitochondrial function. Effective treatments are limited, and current management includes therapies directed at enhancing mitochondrial function and preventing oxidative damage, as well as genetic counselling, and supportive and symptomatic measures. New therapies, including gene therapy, are emerging via animal models and human clinical trials. Leber hereditary optic neuropathy, in particular, provides a unique model for testing promising treatments owing to its characteristic sequential bilateral involvement and the accessibility of target tissue within the eye. Lessons learned from treatment of the hereditary optic neuropathies may have therapeutic implications for other disorders of presumed mitochondrial dysfunction."
According to the news reporters, the research concluded: "In this Review, the natural history of the common inherited optic neuropathies, the presumed pathogenesis of several of these disorders, and the literature to date regarding potential therapies are summarized."
For more information on this research see: Treatment of hereditary optic neuropathies. Nature Reviews Neurology, 2012;8(10):545-56. (Nature Publishing Group - www.nature.com/; Nature Reviews Neurology - www.nature.com/nrneurol/)
Our news correspondents report that additional information may be obtained by contacting N.J. Newman, Neuro-ophthalmology Unit, Dept. of Ophthalmology, Neurology and Neurological Surgery, Emory University School of Medicine, 1365-B Clifton Road NE, Atlanta, GA 30322, United States (see also Neuropathy).
Keywords for this news article include: Biotechnology, Atlanta, Georgia, Genetics, Treatment, Neuropathy, Gene Therapy, Therapeutics, United States, Bioengineering, North and Central America, Clinical Trials and Studies.
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