By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Investigators discuss new findings in Autoimmune Diseases and Disorders. According to news reporting from Campinas, Brazil, by NewsRx journalists, research stated, "Both Th1 and Th17 cells specific for neuroantigen are described as encephalitogenic in the experimental autoimmune encephalomyelitis (EAE) model. The proposal of this study was to investigate how carbon nanotubes internalized by antigen-presenting cells (APCs) affect the development of encephalitogenic CD4(+) T cells."
The news correspondents obtained a quote from the research from the State University of Campinas, "Therefore, we stimulated encephalitogenic T cells in the presence or not of multiwalled carbon nanotube (MWCNT). After the incubation, we analyzed the expression profile of the encephalitogenic T cells and their capacity to induce EAE. Encephalitogenic CD4(+) T cells cultured with APCs that were previously incubated with MWCNTs do not express IL-17. The adoptive transfer of these cells causes less severe EAE than the transfer of both Th1 and Th17 cells that are not incubated with MWCNTs. These results suggest that the increased IL-27 level produced by the APCs incubated with the carbon nanotubes inhibits the development of Th17 cells. This observation is confirmed by the concomitant reduction in the level of RORt, which is a transcription factor essential for the development of Th17 cells. Moreover, the incubation of encephalitogenic T cells devoid of Th17 cells with neutralizing anti-IL-27 antibodies restored the production of IL-17. This finding confirms the suppressive effect of IL-27 on encephalitogenic Th17 cells."
According to the news reporters, the research concluded: "The results presented suggest that the stimulation of APCs with carbon nanoparticles prior to neuroantigen presentation affects the development of the Th17 subset of encephalitogenic CD4(+) T lymphocytes and results in less severe EAE."
For more information on this research see: The Suppressive Effect of IL-27 on Encephalitogenic Th17 Cells Induced by Multiwalled Carbon Nanotubes Reduces the Severity of Experimental Autoimmune Encephalomyelitis. CNS Neuroscience & Therapeutics, 2013;19(9):682-687. CNS Neuroscience & Therapeutics can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; CNS Neuroscience & Therapeutics - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1755-5949)
Our news journalists report that additional information may be obtained by contacting A.S. Moraes, Univ Campinas UNICAMP, Campinas, SP, Brazil. Additional authors for this research include R.F.O. Paula, F. Pradella, M.P.A. Santos, E.C. Oliveira, F. von Glehn, D.S. Camilo, H. Ceragioli, A. Peterlevitz, V. Baranauskas, W. Volpini, A.S. Farias and L.M.B. Santos (see also Autoimmune Diseases and Disorders).
Keywords for this news article include: Brazil, Campinas, Fullerenes, Immunology, CD Antigens, CD4 Antigens, Encephalitis, South America, HIV Receptors, Brain Diseases, Nanotechnology, Differentiation, Membrane Proteins, Biological Factors, Emerging Technologies, T-Lymphocyte Antigens, Interleukin-16 Receptors, Multiwalled Carbon Nanotube
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