By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Oncology. According to news reporting originating from Guilin, People's Republic of China, by NewsRx correspondents, research stated, "Currently, the major challenge for cancer treatment is to develop new types of smart nanocarriers that can efficiently retain the encapsulated drug during blood circulation and quickly release the drug in tumor cells under stimulation. In this study, the dual pH-/light-responsive crosslinked polymeric micelles (CPM) were successfully prepared by the self-assembly of amphiphilic glycol chitosan-o-nitrobenzyl succinate conjugates (GC-NBSCs) and then cross-linking with glutaraldehyde (GA), which was synthesized by grafting hydrophobic light-sensitive o-nitrobenzyl succinate (NBS) onto the main chain of hydrophilic glycol chitosan (GC)."
Our news editors obtained a quote from the research from the Guilin University of Technology, "The GC-NBSC CPMs exhibited good biocompatibility according to the MTT assay against NIH/3T3 cells. The cell viability was maintained higher than 75% after 24 h incubation with CPMs even at a high concentration of 1.0 mg mL(-1). The hydrophobic anticancer drug camptothecin (CPT) was selected as a model drug and loaded into GC-NBSC CPMs. The results of in vitro evaluation showed that the encapsulated CPT could be quickly released at low pH with the light irradiation. Meanwhile, the CPT-loaded CPMs displayed a better cytotoxicity against MCF-7 cancer cells under UV irradiation, and IC50 of the loaded CPT was as low as 2.3 mu g mL(-1), which was close to that of the free CPT (1.5 mu g mL(-1)). Furthermore, the flow cytometry and confocal laser scanning microscopy (CLSM) measurements confirmed that the CPT-loaded CPMs could be internalized by MCF-7 cells efficiently and release CPT inside the tumor cells to enhance the inhibition of cell proliferation."
According to the news editors, the research concluded: "Thereby, such excellent GC-NBSC CPMs provide a favorable platform to construct smart drug delivery systems (DDS) for cancer therapy."
For more information on this research see: Chitosan-Based Nanocarriers with pH and Light Dual Response for Anticancer Drug Delivery. Biomacromolecules, 2013;14(8):2601-2610. Biomacromolecules can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Biomacromolecules - www.pubs.acs.org/journal/bomaf6)
The news editors report that additional information may be obtained by contacting L.L. Meng, Guilin Univ Technol, Sch Mat Sci & Engn, Guilin 541004, People's Republic of China. Additional authors for this research include W. Huang, D.L. Wang, X.H. Huang, X.Y. Zhu and D.Y. Yan (see also Oncology).
Keywords for this news article include: Asia, Guilin, Cancer, Therapy, Oncology, Nanocarriers, Nanotechnology, Drug Delivery Systems, Emerging Technologies, People's Republic of China
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