By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators publish new report on Computers. According to news reporting out of Ribeirao Preto, Brazil, by NewsRx editors, research stated, "We investigated the reproducibility of a semiautomated method (computerized with manual intervention) for nerve morphometry (counting and measuring myelinated fibers) between three observers with different levels of expertise and experience with the method. Comparisons between automatic (fully computerized) and semiautomated morphometric methods performed by the same computer software using the same nerve images were also performed."
Our news journalists obtained a quote from the research from the University of Sao Paulo, "Sural nerves of normal adult rats were used. Automatic and semiautomated morphometry of the myelinated fibers were made through the computer software KS-400. Semiautomated morphometry was conducted by three independent observers on the same images, using the semiautomated method. Automatic morphometry overestimated the myelin sheath area, thus overestimating the myelinated fiber size and underestimating the axon size. Fiber distributions overestimation was of 0.5? ? m. For the semiautomated morphometry, no differences were found between observers for myelinated fiber and axon size distributions. Overestimation of the myelin sheath size of normal fibers by the fully automatic method might have an impact when morphometry is used for diagnostic purposes."
According to the news editors, the research concluded: "We suggest that not only semiautomated morphometry results can be compared between different centers in clinical trials but it can also be performed by more than one investigator in one single experiment, being a reliable and reproducible method."
For more information on this research see: Reproducibility in nerve morphometry: comparison between methods and among observers. Biomed Research International, 2013;2013():682849 (see also Computers).
Our news journalists report that additional information may be obtained by contacting A.P. Bilego Neto, Dept. of Neurosciences and Behavioral Neurosciences, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049-900 Ribeirao Preto, SP, Brazil. Additional authors for this research include F.B. Silveira, G.A. Rodrigues da Silva, L.S. Sanada and V.P Fazan.
Keywords for this news article include: Brazil, Software, Computers, South America, Ribeirao Preto, Clinical Trials and Studies.
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