By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Drugs and Therapies have been published. According to news originating from Orangeburg, New York, by NewsRx correspondents, research stated, "The biodegradable polymer drug-eluting stents have been proposed as an alternative to durable polymer DES, theoretically improving vessel healing and reducing the need for prolonged double anti platelet therapy (DAPT), however clinical significance of this technology is under debate. Therefore, we sought to compare the clinical outcomes of two Paclitaxel eluting stents (PES) containing different polymer-based eluting matrices."
Our news journalists obtained a quote from the research from Cardiovascular Research Foundation, "In this multicenter registry of 392 consecutive patients who underwent PCI between June 2006 and September 2008, we included patients with stable angina or NSTE-ACS displaying at least one significant lesion (>50% diameter stenosis) in native coronary arteries. Biodegradable polymer PES (BP-PES, LUC Chopin(2), Balton, Poland) was implanted in 206 patients, whereas durable polymer PES (DP-PES, Taxus, Boston Scientific, USA) was implanted in 186 patients. There were no significant differences in baseline characteristics between groups with the exception of increased diabetes and number of lesions for BP-PES. In risk-unadjusted analysis at 1-year follow-up, there were no significant differences in TLR (BP-PES: 8.4% vs. DP-PES: 6%; P = 0.36), TVR (BP-PES: 11.1% vs. DP-PES: 8.4%; P = 0.36) and incidence of stent thromboses (BP-PES: 2.15% vs. DP-PES: 3.4%; P = 0.42) between groups. There was also no difference in MACCE between groups (17.6% vs. 14.4%, P = 0.49). The mean dual antiplatelet therapy (DAPT) compliance at 1 year was 77% for BP-PES versus 92% for DP-PES (P = 0.03). Kaplan-Meier analysis showed a significantly higher long-term stroke free survival in BP-PES (P = 0.04). After adjustment, this was sustained with an additional tendency toward higher MI free survival for BP-PES (P = 0.059)."
According to the news editors, the research concluded: "In this observational analysis, BP-PES were comparable to DP-PES, with regard to incidence of repeated revascularizations, stent thromboses and MACCE despite earlier DAPT discontinuation."
For more information on this research see: Comparable clinical safety and efficacy of biodegradable versus durable polymer paclitaxel eluting stents despite shorter dual antiplatelet therapy: Insights from a multicenter, propensity score-matched registry. Catheterization and Cardiovascular Interventions, 2013;82(3):E155-E162. Catheterization and Cardiovascular Interventions can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Catheterization and Cardiovascular Interventions - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1522-726X)
The news correspondents report that additional information may be obtained from P.P. Buszman, Cardiovasc Res Fdn, Skirball Center Cardiovasc Res, Orangeburg, NY, United States. Additional authors for this research include B. Orlik, B. Trela, K. Milewski, M. Kozlowski, M. Pruski, J. Drzewiecki, A. Peppas, J.F. Granada, G.L. Kaluza and P.E. Buszman (see also Drugs and Therapies).
Keywords for this news article include: Antineoplastics, Pharmaceuticals, Taxoids, New York, Terpenes, Orangeburg, Paclitaxel, Hydrocarbons, United States, Cycloparaffins, Organic Chemicals, Mitotic Inhibitors, Drugs and Therapies, North and Central America
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC