By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Biotechnology. According to news reporting out of Atlanta, Georgia, by NewsRx editors, research stated, "The aortic valve (AV) experiences a complex mechanical environment, which includes tension, flexure, pressure, and shear stress forces due to blood flow during each cardiac cycle. This mechanical environment regulates AV tissue structure by constantly renewing and remodeling the phenotype."
Our news journalists obtained a quote from the research from the Georgia Institute of Technology and Emory University, "In vitro, ex vivo and in vivo studies have shown that pathological states such as hypertension and congenital defect like bicuspid AV (BAV) can potentially alter the AV's mechanical environment, triggering a cascade of remodeling, inflammation, and calcification activities in AV tissue. Alteration in mechanical environment is first sensed by the endothelium, which in turn induces changes in the extracellular matrix, and triggers cell differentiation and activation. However, the molecular mechanism of this process is not understood very well. Understanding these mechanisms is critical for advancing the development of effective medical based therapies. Recently, there have been some interesting studies on characterizing the hemodynamics associated with AV, especially in pathologies like BAV, using different experimental and numerical methods."
According to the news editors, the research concluded: "Here, we review the current knowledge of the local AV mechanical environment and its effect on valve biology, focusing on in vitro and ex vivo approaches."
For more information on this research see: Aortic valve: mechanical environment and mechanobiology. Annals of Biomedical Engineering, 2013;41(7):1331-46. Annals of Biomedical Engineering can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer - www.springer.com; Annals of Biomedical Engineering - www.springerlink.com/content/0090-6964/)
Our news journalists report that additional information may be obtained by contacting S. Arjunon, The Wallace H Coulter Dept. of Biomedical Engineering, Georgia Institute of Technology and Emory University, Room 2119 U A Whitaker Building, 313 Ferst Drive, Atlanta, GA 30332-0535, United States. Additional authors for this research include S. Rathan, H. Jo and A.P Yoganathan (see also technology.html">Biotechnology).
Publisher contact information for the journal Annals of Biomedical Engineering is: Springer, 233 Spring Street, New York, NY 10013, USA.
Keywords for this news article include: Biotechnology, Atlanta, Georgia, United States, North and Central America.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC