By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Researchers detail new data in Nanoparticles. According to news reporting originating from Wuhan, People's Republic of China, by NewsRx correspondents, research stated, "Previous study showed that hydroxyapatite nanoparticles (nano-HAPs) inhibited glioma growth in vitro and in vivo; and in a drug combination, they could reduce adverse reactions. We investigated the possible enhancement of radiosensitivity induced by nano-HAPs."
Our news editors obtained a quote from the research from Wuhan University, "In vitro radiosensitization of nano-HAPs was measured using a clonogenic survival assay in human glioblastoma U251 and breast tumor brain metastatic tumor MDA-MB-231BR cells. DNA damage and repair were measured using gamma H2AX foci, and mitotic catastrophe was determined by immunostaining. The effect of nano-HAPs on in vivo tumor radiosensitivity was investigated in a subcutaneous and an orthotopic model. Nano-HAPs enhanced each cell line's radiosensitivity when the exposure was 1 h before irradiation, and they had no significant effect on irradiation-induced apoptosis or on the activation of the G(2) cell cycle checkpoint. The number of gamma H2AX foci per cell was significantly large at 24 h after the combination modality of nano-HAPs + irradiation compared with single treatments. Mitotic catastrophe was also significantly increased at an interval of 72 h in tumor cells receiving the combined modality compared with the individual treatments. In a subcutaneous model, nano-HAPs caused a larger than additive increase in tumor growth delay. In an orthotopic model, nano-HAPs significantly reduced tumor growth and extended the prolongation of survival induced by irradiation."
According to the news editors, the research concluded: "These results show that nano-HAPs can enhance the radiosensitivity of tumor cells in vitro and in vivo through the inhibition of DNA repair, resulting in an increase in mitotic catastrophe."
For more information on this research see: In vitro and in vivo radiosensitization induced by hydroxyapatite nanoparticles. Neuro-Oncology, 2013;15(7):880-890. Neuro-Oncology can be contacted at: Oxford Univ Press Inc, Journals Dept, 2001 Evans Rd, Cary, NC 27513, USA. (Oxford University Press - www.oup.com/; Neuro-Oncology - neuro-oncology.oxfordjournals.org)
The news editors report that additional information may be obtained by contacting S.H. Chu, Wuhan University, Zhongnan Hosp, Dept. of Neurosurg, Wuhan 430072, People's Republic of China. Additional authors for this research include S. Karri, Y.B. Ma, D.F. Feng and Z.Q. Li (see also Nanoparticles).
Keywords for this news article include: Asia, Wuhan, Nanotechnology, Emerging Technologies, People's Republic of China
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