By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Drugs and Therapies have been published. According to news originating from Beijing, People's Republic of China, by NewsRx correspondents, research stated, "Transferrin (Tf), an iron-transporting serum glycoprotein that binds to receptors overexpressed at the surface of glioma cells, was chosen as the ligand to develop Tf-conjugated PEGylated nanoscaled graphene oxide (GO) for loading and glioma targeting delivery of anticancer drug doxorubicin (Dox) (Tf-PEG-GO-Dox). Tf-GO with lateral dimensions of 100-400 nm exhibited a Dox loading ratio up to 115.4%."
Our news journalists obtained a quote from the research from the Institute of Chemistry, "Compared with Dox-loaded PEGylated GO (PEG-GO-Dox) and free Dox, Tf-PEG-GO-Dox displayed greater intracellular delivery efficiency and stronger cytotoxicity against C6 glioma cells. A competition test showed that Tf was essential to glioma targeting in vitro. The HPLC assay for Dox concentration in tumor tissue and contrapart tissue of the brain demonstrated that Tf-PEG-GO-Dox could deliver more Dox into tumor in vivo."
According to the news editors, the research concluded: "The life span of tumor bearing rats after the administration of Tf-PEG-GO-Dox was extended significantly compared to the rats treated with saline, Dox, and PEG-GO-Dox we developed Tf-PEG-GO-Dox which exhibited significantly improved therapeutic efficacy for glioma both in vitro and in vivo."
For more information on this research see: Transferrin Modified Graphene Oxide for Glioma-Targeted Drug Delivery: In Vitro and in Vivo Evaluations. ACS Applied Materials & Interfaces, 2013;5(15):6909-6914. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)
The news correspondents report that additional information may be obtained from G.D. Liu, Chinese Academy Sci, Inst Chem, Beijing 100190, People's Republic of China. Additional authors for this research include H. Shen, J.N. Mao, L.M. Zhang, Z. Jiang, T. Sun, Q. Lan and Z.J. Zhang (see also Drugs and Therapies).
Keywords for this news article include: Asia, Beijing, Transferrin, Beta-Globulins, Blood Proteins, Drugs and Therapies, Acute-Phase Proteins, Drug Delivery Systems, Iron-Binding Proteins, People's Republic of China
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