Patent number 8530417 is assigned to
The following quote was obtained by the news editors from the background information supplied by the inventors: "Granulocyte colony stimulating factor (G-CSF) is one of the colony stimulating factors that contribute to the formation of the colonies of bone marrow cells. It can specifically stimulate and regulate the proliferation, differentiation, survival and activation of granulocytes, and is promising in treating granulopenia of various causes.
"Human G-CSF gene is located in the q21-22 region on chromosome 17 with a full length of 2.5 kb. The gene is consisted of 5 exons and 4 introns, and the corresponding mature protein comprises 174 amino acids. G-CSF expressed by E. coli has a Met on its N-terminus, and is consisted of 175 amino acids, as shown in FIG. 1 (SEQ ID NO:1). The molecule comprises 5 cystein residues, wherein Cys37-Cys43 and Cys75-Cys85 form two pairs of disulfide bonds, and comprises 4 lysine residues, located on positions 17, 24, 35 and 41 separately.
"Neutropenia caused by chemotherapy, especially febril neutropenia (FN) is the most common and usually the most serious side effect after chemotherapy of cancer patients, especially in the first cycle of chemotherapy. FN will lead to enforced hospitalization and use of antibiotics, causing extra economic burden and high fatality. Another damaging result is that due to the reduction of neutrophils, the scheme for the treatment of cancer patients has to be changed, for example reducing the dosage for chemotherapy and postponing the next therapeutic cycle, which are directly related to the final therapeutic result. Since the approval of rHuG-CSF by
Most Popular Stories
- Boehner Lashes Out Against Ted Cruz, Far Right
- Hawaii Official Who Release Obama Certificate Only Victim of Plane Crash
- Ted Cruz Coloring Book Selling Briskly
- Ford Plans New Cars, Jobs in 2014
- Kim Jong Un's Uncle Executed
- 'Rape Insurance' Bill Passes in Michigan
- Gold, Silver Slide on Prospects of Fed Exit
- Holiday Shopping Off to a Slow Start This Season
- Grizzly Bears Could Be Taken Off Endangered List
- TFA Recruiting DACA Recipients